Alpha–streptococcal septicemia in leukemic children treated with continuous or large dosage intermittent cytosine arabinoside

Sara V. Sotiropoulos, Mary Anne Jackson, Gerald M. Woods, Ralph Hicks, John Cullen, Arnold I. Freeman

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

During a 2-year period after the introduction of an intensive chemotherapeutic protocol, alpha-hemolytic streptococci accounted for 75% of all episodes of sepsis among children with acute nonlymphocytic leukemia at our institution. Only one case had occurred in the previous 8 years. Fourteen of 15 episodes of streptococcal sepsis occurred after therapy with either continuous or large dosage intermittent cytosine arabinoside. Eleven episodes occurred at two specific treatment points. Septic episodes were complicated by shock (2 of 15), encephalopathy (2 of 15), pneumonia (3 of 15) and death (1 of 15). Oral mucosal lesions may provide a portal of entry for alpha-hemolytic streptococci. These data suggest that children receiving continuous or large dosage intermittent cytosine arabinoside for treatment of acute nonlymphocytic leukemia may be at increased risk for alpha-he- molytic streptococcal sepsis. Empiric antimicrobial therapy in these children when febrile and neutropenic should include antibiotics effective against alpha-hemolytic streptococci.

Original languageEnglish (US)
Pages (from-to)755-758
Number of pages4
JournalPediatric Infectious Disease Journal
Volume8
Issue number11
StatePublished - 1989
Externally publishedYes

Fingerprint

Cytarabine
Sepsis
Streptococcus
Acute Myeloid Leukemia
Brain Diseases
Therapeutics
Shock
Pneumonia
Fever
Anti-Bacterial Agents

Keywords

  • Acute non-lymphocytic leukemia
  • Alpha-hemolytic streptococci
  • Cytosine arabinoside

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health

Cite this

Alpha–streptococcal septicemia in leukemic children treated with continuous or large dosage intermittent cytosine arabinoside. / Sotiropoulos, Sara V.; Jackson, Mary Anne; Woods, Gerald M.; Hicks, Ralph; Cullen, John; Freeman, Arnold I.

In: Pediatric Infectious Disease Journal, Vol. 8, No. 11, 1989, p. 755-758.

Research output: Contribution to journalArticle

Sotiropoulos, Sara V. ; Jackson, Mary Anne ; Woods, Gerald M. ; Hicks, Ralph ; Cullen, John ; Freeman, Arnold I. / Alpha–streptococcal septicemia in leukemic children treated with continuous or large dosage intermittent cytosine arabinoside. In: Pediatric Infectious Disease Journal. 1989 ; Vol. 8, No. 11. pp. 755-758.
@article{bd7265fd64844a69a62d3bf7807d528c,
title = "Alpha–streptococcal septicemia in leukemic children treated with continuous or large dosage intermittent cytosine arabinoside",
abstract = "During a 2-year period after the introduction of an intensive chemotherapeutic protocol, alpha-hemolytic streptococci accounted for 75{\%} of all episodes of sepsis among children with acute nonlymphocytic leukemia at our institution. Only one case had occurred in the previous 8 years. Fourteen of 15 episodes of streptococcal sepsis occurred after therapy with either continuous or large dosage intermittent cytosine arabinoside. Eleven episodes occurred at two specific treatment points. Septic episodes were complicated by shock (2 of 15), encephalopathy (2 of 15), pneumonia (3 of 15) and death (1 of 15). Oral mucosal lesions may provide a portal of entry for alpha-hemolytic streptococci. These data suggest that children receiving continuous or large dosage intermittent cytosine arabinoside for treatment of acute nonlymphocytic leukemia may be at increased risk for alpha-he- molytic streptococcal sepsis. Empiric antimicrobial therapy in these children when febrile and neutropenic should include antibiotics effective against alpha-hemolytic streptococci.",
keywords = "Acute non-lymphocytic leukemia, Alpha-hemolytic streptococci, Cytosine arabinoside",
author = "Sotiropoulos, {Sara V.} and Jackson, {Mary Anne} and Woods, {Gerald M.} and Ralph Hicks and John Cullen and Freeman, {Arnold I.}",
year = "1989",
language = "English (US)",
volume = "8",
pages = "755--758",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Alpha–streptococcal septicemia in leukemic children treated with continuous or large dosage intermittent cytosine arabinoside

AU - Sotiropoulos, Sara V.

AU - Jackson, Mary Anne

AU - Woods, Gerald M.

AU - Hicks, Ralph

AU - Cullen, John

AU - Freeman, Arnold I.

PY - 1989

Y1 - 1989

N2 - During a 2-year period after the introduction of an intensive chemotherapeutic protocol, alpha-hemolytic streptococci accounted for 75% of all episodes of sepsis among children with acute nonlymphocytic leukemia at our institution. Only one case had occurred in the previous 8 years. Fourteen of 15 episodes of streptococcal sepsis occurred after therapy with either continuous or large dosage intermittent cytosine arabinoside. Eleven episodes occurred at two specific treatment points. Septic episodes were complicated by shock (2 of 15), encephalopathy (2 of 15), pneumonia (3 of 15) and death (1 of 15). Oral mucosal lesions may provide a portal of entry for alpha-hemolytic streptococci. These data suggest that children receiving continuous or large dosage intermittent cytosine arabinoside for treatment of acute nonlymphocytic leukemia may be at increased risk for alpha-he- molytic streptococcal sepsis. Empiric antimicrobial therapy in these children when febrile and neutropenic should include antibiotics effective against alpha-hemolytic streptococci.

AB - During a 2-year period after the introduction of an intensive chemotherapeutic protocol, alpha-hemolytic streptococci accounted for 75% of all episodes of sepsis among children with acute nonlymphocytic leukemia at our institution. Only one case had occurred in the previous 8 years. Fourteen of 15 episodes of streptococcal sepsis occurred after therapy with either continuous or large dosage intermittent cytosine arabinoside. Eleven episodes occurred at two specific treatment points. Septic episodes were complicated by shock (2 of 15), encephalopathy (2 of 15), pneumonia (3 of 15) and death (1 of 15). Oral mucosal lesions may provide a portal of entry for alpha-hemolytic streptococci. These data suggest that children receiving continuous or large dosage intermittent cytosine arabinoside for treatment of acute nonlymphocytic leukemia may be at increased risk for alpha-he- molytic streptococcal sepsis. Empiric antimicrobial therapy in these children when febrile and neutropenic should include antibiotics effective against alpha-hemolytic streptococci.

KW - Acute non-lymphocytic leukemia

KW - Alpha-hemolytic streptococci

KW - Cytosine arabinoside

UR - http://www.scopus.com/inward/record.url?scp=0024358821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024358821&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 755

EP - 758

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 11

ER -