Alpha2-adrenergic receptor function in patients with unipolar and bipolar affective disorders

Marian S. Kafka, John I. Nurnberger, Larry Siever, Steven Targum, Thomas W. Uhde, Elliot S. Gershon

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Alpha2-adrenergic receptor function was measured in platelets from unipolar (UP) depressed, bipolar (BP) depressed, and bipolar euthymic patients and normal control subjects. Only the platelets from UP depressed patients were different from control in having an increased number of α2-receptors, a decreased percent norepinephrine inhibition of prostaglandin E1 (PGE1)-stimulated cyclic AMP (cAMP) production, and a decrease in PGE1 stimulation of cAMP production. Platelets from BP patients, depressed or euthymic, were not significantly different from control subjects. These preliminary data suggest that α2-adrenergic receptor function and PGE1 stimulation of cAMP production are diminished in UP patients.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalJournal of Affective Disorders
Issue number2
StatePublished - Jan 1 1986
Externally publishedYes


  • Affective disorders
  • Alpha-adrenergic receptor
  • Cyclic AMP
  • Platelet

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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