Alprazolam attenuates metabolic stress-induced neuroendocrine and behavioral effects in humans

Alan Breier, Orlando R. Davis, Robert W. Buchanan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effects of benzodiazepine drugs and the role of their recognition site, the GABAA/benzodiazepine receptor, in acute glucoprivic stress are not known. In the present study, the effects of acute glucoprivation were examined in ten healthy human subjects. Glucoprivation was induced by infusion of the glucose analog, 2-deoxyglucose (2DG), at doses sufficient (50 mg/kg) to competitively inhibit glucose metabolism. In addition, the effects of the triazolobenzodiazepine alprazolam (1.5 mg) on the 2DG-induced stress response was assessed. 2DG produced significant elevations in plamsa cortisol (P=0.0001) and glucose (P=0.0003) levels. Alprazolam pretreatment attenuated the 2DG-related cortisol elevations (P=0.05) but did not effect 2DG-induced glucose increases. In addition, 2DG caused significant increases in hunger (P=0.01) and thirst (P=0.001), and alprazolam significantly blunted both of these responses. Lastly, 2DG had significant effects on heart rate, diastolic blood pressure and body temperature (P

Original languageEnglish (US)
Pages (from-to)479-484
Number of pages6
JournalPsychopharmacology
Volume104
Issue number4
DOIs
StatePublished - Aug 1991
Externally publishedYes

Fingerprint

Alprazolam
Physiological Stress
Deoxyglucose
Glucose
GABA-A Receptors
Hydrocortisone
Blood Pressure
Thirst
Hunger
Body Temperature
Benzodiazepines
Healthy Volunteers
Heart Rate

Keywords

  • Behavioral response
  • Benzodiazepines
  • Cortisol
  • Glucoprivation
  • Metabolic stress

ASJC Scopus subject areas

  • Pharmacology

Cite this

Alprazolam attenuates metabolic stress-induced neuroendocrine and behavioral effects in humans. / Breier, Alan; Davis, Orlando R.; Buchanan, Robert W.

In: Psychopharmacology, Vol. 104, No. 4, 08.1991, p. 479-484.

Research output: Contribution to journalArticle

Breier, Alan ; Davis, Orlando R. ; Buchanan, Robert W. / Alprazolam attenuates metabolic stress-induced neuroendocrine and behavioral effects in humans. In: Psychopharmacology. 1991 ; Vol. 104, No. 4. pp. 479-484.
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