Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to Mitral Regurgitation

Sander Verheule, Emily Wilson, Thomas Everett, Sujata Shanbhag, Catherine Golden, Jeffrey Olgin

Research output: Contribution to journalArticle

239 Citations (Scopus)

Abstract

Background - Clinically, chronic atrial dilatation is associated with an increased incidence of atrial fibrillation (AF), but the underlying mechanism is not clear. We have investigated atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to mitral regurgitation (MR). Methods and Results - Thirteen control and 19 MR dogs (1 month after partial mitral valve avulsion) were studied. Dogs in the MR group were monitored using echocardiography and Holter recording. In open-chest follow-up experiments, electrode arrays were placed on the atria to investigate conduction patterns, effective refractory periods, and inducibility of AF. Alterations in tissue structure and ultrastructure were assessed in atrial tissue samples. At follow-up, left atrial length in MR dogs was 4.09±0.45 cm, compared with 3.25±0.28 at baseline (P<0.01), corresponding to a volume of 205±61% of baseline. At follow-up, no differences in atrial conduction pattern and conduction velocities were noted between control and MR dogs. Effective refractory periods were increased homogeneously throughout the left and right atrium. Sustained AF (>1 hour) was inducible in 10 of 19 MR dogs and none of 13 control dogs (P<0.01). In the dilated MR left atrium, areas of increased interstitial fibrosis and chronic inflammation were accompanied by increased glycogen ultrastructurally. Conclusions - Chronic atrial dilatation in the absence of overt heart failure leads to an increased vulnerability to AF that is not based on a decrease in wavelength.

Original languageEnglish (US)
Pages (from-to)2615-2622
Number of pages8
JournalCirculation
Volume107
Issue number20
StatePublished - May 27 2003
Externally publishedYes

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Electrophysiology
Mitral Valve Insufficiency
Canidae
Dilatation
Dogs
Atrial Fibrillation
Heart Atria
Glycogen
Mitral Valve
Echocardiography
Electrodes
Fibrosis
Thorax
Heart Failure
Inflammation
Incidence

Keywords

  • Electrophysiology
  • Fibrillation
  • Tissue

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to Mitral Regurgitation. / Verheule, Sander; Wilson, Emily; Everett, Thomas; Shanbhag, Sujata; Golden, Catherine; Olgin, Jeffrey.

In: Circulation, Vol. 107, No. 20, 27.05.2003, p. 2615-2622.

Research output: Contribution to journalArticle

Verheule, Sander ; Wilson, Emily ; Everett, Thomas ; Shanbhag, Sujata ; Golden, Catherine ; Olgin, Jeffrey. / Alterations in atrial electrophysiology and tissue structure in a canine model of chronic atrial dilatation due to Mitral Regurgitation. In: Circulation. 2003 ; Vol. 107, No. 20. pp. 2615-2622.
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