Alterations in brain structure and function in breast cancer survivors: Effect of post-chemotherapy interval and relation to oxidative DNA damage

Susan K. Conroy, Brenna McDonald, Dori J. Smith, Lyndsi R. Moser, John D. West, Lisa M. Kamendulis, James E. Klaunig, Victoria Champion, Frederick Unverzagt, Andrew Saykin

Research output: Contribution to journalArticle

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Abstract

Neuroimaging studies have begun to uncover the neural substrates of cancer and treatment-related cognitive dysfunction, but the time course of these changes in the years following chemotherapy is unclear. This study analyzed multimodality 3T MRI scans to examine the structural and functional effects of chemotherapy and post-chemotherapy interval (PCI) in a cohort of breast cancer survivors (BCS; n = 24; PCI mean 6, range 3-10 y) relative to age- and education-matched healthy controls (HC; n = 23). Assessments included voxel-based morphometry for gray matter density (GMD) and fMRI for activation profile during a 3-back working memory task. The relationships between brain regions associated with PCI and neuropsychological performance, self-reported cognition, and oxidative and direct DNA damage as measured in peripheral lymphocytes were assessed in secondary analyses. PCI was positively associated with GMD and activation on fMRI in the right anterior frontal region (Brodmann Areas 9 and 10) independent of participant age. GMD in this region was also positively correlated with global neuropsychological function. Memory dysfunction, cognitive complaints, and oxidative DNA damages were increased in BCS compared with HC. Imaging results indicated lower fMRI activation in several regions in the BCS group. BCS also had lower GMD than HC in several regions, and in these regions, GMD was inversely related to oxidative DNA damage and learning and memory neuropsychological domain scores. This is the first study to show structural and functional effects of PCI and to relate oxidative DNA damage to brain alterations in BCS. The relationship between neuroimaging and cognitive function indicates the potential clinical relevance of these findings. The relationship with oxidative DNA damage provides a mechanistic clue warranting further investigation.

Original languageEnglish
Pages (from-to)493-502
Number of pages10
JournalBreast Cancer Research and Treatment
Volume137
Issue number2
DOIs
StatePublished - Jan 2013

Fingerprint

DNA Damage
Breast Neoplasms
Drug Therapy
Brain
Magnetic Resonance Imaging
Neuroimaging
Cognition
Second Primary Neoplasms
Short-Term Memory
Gray Matter
Learning
Lymphocytes
Education

Keywords

  • Breast cancer
  • Chemotherapy
  • DNA damage
  • Functional MRI
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Alterations in brain structure and function in breast cancer survivors : Effect of post-chemotherapy interval and relation to oxidative DNA damage. / Conroy, Susan K.; McDonald, Brenna; Smith, Dori J.; Moser, Lyndsi R.; West, John D.; Kamendulis, Lisa M.; Klaunig, James E.; Champion, Victoria; Unverzagt, Frederick; Saykin, Andrew.

In: Breast Cancer Research and Treatment, Vol. 137, No. 2, 01.2013, p. 493-502.

Research output: Contribution to journalArticle

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