Alterations in dopamine and serotonin uptake systems in the striatum of the weaver mutant mouse

E. H. Stotz, J. M. Palacios, B. Landwehrmeyer, J. Norton, B. Ghetti, J. R. Simon, L. C. Triarhou

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16 Scopus citations

Abstract

In the striatum of the homozygous weaver mutant mouse (wv/wv), dopamine content, uptake and tyrosine hydroxylase activity are decreased compared to wild-type (+/+) mice. In mice heterozygous for the weaver gene (wv/+), these dopaminergic parameters exhibit only minor reductions compared to +/+ mice. The wv/wv striatum has recently been shown to have an increase in serotonin content. In the present study, the serotonin uptake system of the weaver striatum was investigated. Synaptosomal uptake of [3H] serotonin was determined in the dorsal portion of wv/wv and +/+ striatum, and serotonin uptake sites were examined by the binding of [3H] citalopram in the striatum of wv/wv, wv/+ and +/+ mice. The dopamine uptake system was also investigated in all three genotypes via the binding of [3H] mazindol. Synaptosomal uptake of [3H] serotonin was increased by 79% in the dorsal portion of the wv/wv striatum compared to that seen in the +/+ striatum. The binding of [3H] citalopram was increased by 62% in the dorsolateral and by 111% in the dorsomedial portions of the wv/wv striatum compared to +/+. [3H] Citalopram binding in the wv/+ striatum was also higher than +/+, but this increase did not reach statistical significance. Within the wv/wv striatum, [3H] mazindol binding was almost completely absent (88-89% reduction) in the dorsal portion and severely reduced in the other striatal areas. These data support the notion that the dorsal portion of the wv/wv striatum, which has the severest reduction in dopamine uptake, is hyperinnervated by serotonin fibers.

Original languageEnglish (US)
Pages (from-to)51-64
Number of pages14
JournalJournal of Neural Transmission
Volume97
Issue number1
DOIs
StatePublished - Feb 1 1994

Keywords

  • autoradiography
  • citalopram binding
  • Dopamine uptake
  • mazindol binding
  • serotonin uptake
  • striatum
  • weaver mutant mouse

ASJC Scopus subject areas

  • Neuroscience(all)

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    Stotz, E. H., Palacios, J. M., Landwehrmeyer, B., Norton, J., Ghetti, B., Simon, J. R., & Triarhou, L. C. (1994). Alterations in dopamine and serotonin uptake systems in the striatum of the weaver mutant mouse. Journal of Neural Transmission, 97(1), 51-64. https://doi.org/10.1007/BF01277962