Alterations in epithelial polarity and the pathogenesis of disease states

Franklin H. Epstein, Eileen M. Fish, Bruce A. Molitoris

Research output: Contribution to journalReview article

180 Scopus citations


The establishment and maintenance of epithelial-cell polarity are prerequisites for normal epithelial-cell and organ function. Knowledge of the processes involved in cell polarity has provided insight into the mechanisms of cell dysfunction and the pathogenesis of several diseases. These insights should lead to the development of specific strategies aimed at preventing or minimizing the progression of these diseases.

Original languageEnglish (US)
Pages (from-to)1580-1588
Number of pages9
JournalNew England Journal of Medicine
Issue number22
StatePublished - Jun 2 1994


ASJC Scopus subject areas

  • Medicine(all)

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