Alterations of pancreatic digestive enzyme content in the manganese-deficient rat

P. M. Brannon, V. P. Collins, Murray Korc

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Previous studies suggest that manganese (Mn) may regulate pancreatic exocrine function. In this study, the effects of Mn deficiency on the pancreatic exocrine enzyme content and postweaning development were examined in male weanling Sprague-Dawley rats fed a high carbohydrate diet 40 ppm Mn (control) or 0.5 ppm Mn (Mn deficient) for 1-10 wk. Pancreatic and hepatic Mn content were 50 and 39% of respective controls in Mn-deficient rats at wk 4. Pancreatic amylase activity was significantly (P <0.05) higher at wk 8 and 10 in Mn-deficient rats than in controls. Mn deficiency did not alter pancreatic lipase, chymotrypsin or trypsin activities. Dietary Mn repletion restored pancreatic Mn content but did not reverse the elevated pancreatic amylase. These results suggest that Mn may play a complex role in the postweaning development of the exocrine pancreas and the regulation of pancreatic amylase.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalJournal of Nutrition
Volume117
Issue number2
StatePublished - 1987
Externally publishedYes

Fingerprint

digestive enzymes
Manganese
manganese
rats
Enzymes
Amylases
amylases
Exocrine Pancreas
high carbohydrate diet
repletion
chymotrypsin
Lipase
weanlings
pancreas
trypsin
triacylglycerol lipase
Sprague Dawley Rats
Carbohydrates
Diet

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Brannon, P. M., Collins, V. P., & Korc, M. (1987). Alterations of pancreatic digestive enzyme content in the manganese-deficient rat. Journal of Nutrition, 117(2), 305-311.

Alterations of pancreatic digestive enzyme content in the manganese-deficient rat. / Brannon, P. M.; Collins, V. P.; Korc, Murray.

In: Journal of Nutrition, Vol. 117, No. 2, 1987, p. 305-311.

Research output: Contribution to journalArticle

Brannon, PM, Collins, VP & Korc, M 1987, 'Alterations of pancreatic digestive enzyme content in the manganese-deficient rat', Journal of Nutrition, vol. 117, no. 2, pp. 305-311.
Brannon, P. M. ; Collins, V. P. ; Korc, Murray. / Alterations of pancreatic digestive enzyme content in the manganese-deficient rat. In: Journal of Nutrition. 1987 ; Vol. 117, No. 2. pp. 305-311.
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