Alterations of the electrophysiological properties from cortical layer 5 pyramidal neurons in temporary rapamycin-treated rodent brain slices

Keming Ren, Lijuan Chen, Guoxia Sheng, Jiangping Wang, Xiaoming Jin, Kewen Jiang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The mammalian target of rapamycin (mTOR) signaling pathway is involved in neuro-developmental/degenerative and neuropsychiatric abnormalities. Rapamycin, a specific and potent inhibitor of mTOR signaling, could regulate synaptic plasticity and synaptic transmission of glutamatergic neurons following prolonged treatment. Its immediate effects on electrophysiological properties of cortical layer 5 (L5) pyramidal neurons where the information undergoes a sophisticated processing remain unknown. Here, we found that acute (within 2min) bath-application of rapamycin (0.5μgml-1) was able to depolarize the current-clamp baseline potentials significantly at postnatal day (P) 4, P10 in rats and P90 in mice (P

Original languageEnglish (US)
Pages (from-to)80-86
Number of pages7
JournalNeuroscience Letters
Volume612
DOIs
StatePublished - Jan 26 2016

Keywords

  • Brain development
  • Cortical layer 5 pyramidal neuron
  • Electrophysiology
  • mTOR signaling
  • Rapamycin

ASJC Scopus subject areas

  • Neuroscience(all)

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