Alterations to maternal cortical and trabecular bone in multiparous middle-aged mice

Alex Gu, R. Sellamuthu, E. Himes, P. J. Childress, Louis Pelus, Christie Orschell, Melissa Kacena

Research output: Contribution to journalArticle

Abstract

Objectives: During the reproductive cycle, altered calcium homeostasis is observed due to variable demand for mineral requirements. This results in increased bone resorption during the time period leading up to parturition and subsequent lactation. During lactation, women will lose 1-3% of bone mineral density per month, which is comparable to the loss experienced on an annual basis post-menopausal. The purpose of this study was to determine the effect of parity on bone formation in middle-aged mice. Methods: Mice were mated and grouped by number of parity and compared with age matched nulliparous controls. Measurements were taken of femoral trabecular and cortical bone. Calcium, protein and alkaline phosphatase levels were also measured. Results: An increase in trabecular bone mineral density was observed when comparing mice that had undergone parity once to the nulliparous control. An overall decrease in trabecular bone mineral density was observed as parity increased from 1 to 5 pregnancies. No alteration was seen in cortical bone formation. No difference was observed when calcium, protein and alkaline phosphatase levels were assessed. Conclusions: This study demonstrates that number of parity has an impact on trabecular bone formation in middle-aged mice, with substantial changes in bone density seen among the parous groups.

Original languageEnglish (US)
Pages (from-to)312-318
Number of pages7
JournalJournal of Musculoskeletal Neuronal Interactions
Volume17
Issue number4
StatePublished - Dec 1 2017

Fingerprint

Parity
Bone Density
Mothers
Osteogenesis
Phosphoprotein Phosphatases
Calcium
Lactation
Alkaline Phosphatase
Bone Resorption
Thigh
Minerals
Homeostasis
Cancellous Bone
Cortical Bone
Parturition
Pregnancy

Keywords

  • Cortical bone
  • Middle age
  • Multiparity
  • Multiple gestations
  • Trabecular bone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Orthopedics and Sports Medicine

Cite this

Alterations to maternal cortical and trabecular bone in multiparous middle-aged mice. / Gu, Alex; Sellamuthu, R.; Himes, E.; Childress, P. J.; Pelus, Louis; Orschell, Christie; Kacena, Melissa.

In: Journal of Musculoskeletal Neuronal Interactions, Vol. 17, No. 4, 01.12.2017, p. 312-318.

Research output: Contribution to journalArticle

Gu, Alex ; Sellamuthu, R. ; Himes, E. ; Childress, P. J. ; Pelus, Louis ; Orschell, Christie ; Kacena, Melissa. / Alterations to maternal cortical and trabecular bone in multiparous middle-aged mice. In: Journal of Musculoskeletal Neuronal Interactions. 2017 ; Vol. 17, No. 4. pp. 312-318.
@article{13f63d170b654f458da368f8ab9a41d2,
title = "Alterations to maternal cortical and trabecular bone in multiparous middle-aged mice",
abstract = "Objectives: During the reproductive cycle, altered calcium homeostasis is observed due to variable demand for mineral requirements. This results in increased bone resorption during the time period leading up to parturition and subsequent lactation. During lactation, women will lose 1-3{\%} of bone mineral density per month, which is comparable to the loss experienced on an annual basis post-menopausal. The purpose of this study was to determine the effect of parity on bone formation in middle-aged mice. Methods: Mice were mated and grouped by number of parity and compared with age matched nulliparous controls. Measurements were taken of femoral trabecular and cortical bone. Calcium, protein and alkaline phosphatase levels were also measured. Results: An increase in trabecular bone mineral density was observed when comparing mice that had undergone parity once to the nulliparous control. An overall decrease in trabecular bone mineral density was observed as parity increased from 1 to 5 pregnancies. No alteration was seen in cortical bone formation. No difference was observed when calcium, protein and alkaline phosphatase levels were assessed. Conclusions: This study demonstrates that number of parity has an impact on trabecular bone formation in middle-aged mice, with substantial changes in bone density seen among the parous groups.",
keywords = "Cortical bone, Middle age, Multiparity, Multiple gestations, Trabecular bone",
author = "Alex Gu and R. Sellamuthu and E. Himes and Childress, {P. J.} and Louis Pelus and Christie Orschell and Melissa Kacena",
year = "2017",
month = "12",
day = "1",
language = "English (US)",
volume = "17",
pages = "312--318",
journal = "Journal of Musculoskeletal Neuronal Interactions",
issn = "1108-7161",
publisher = "International Society of Musculoskeletal and Neuronal Interactions",
number = "4",

}

TY - JOUR

T1 - Alterations to maternal cortical and trabecular bone in multiparous middle-aged mice

AU - Gu, Alex

AU - Sellamuthu, R.

AU - Himes, E.

AU - Childress, P. J.

AU - Pelus, Louis

AU - Orschell, Christie

AU - Kacena, Melissa

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Objectives: During the reproductive cycle, altered calcium homeostasis is observed due to variable demand for mineral requirements. This results in increased bone resorption during the time period leading up to parturition and subsequent lactation. During lactation, women will lose 1-3% of bone mineral density per month, which is comparable to the loss experienced on an annual basis post-menopausal. The purpose of this study was to determine the effect of parity on bone formation in middle-aged mice. Methods: Mice were mated and grouped by number of parity and compared with age matched nulliparous controls. Measurements were taken of femoral trabecular and cortical bone. Calcium, protein and alkaline phosphatase levels were also measured. Results: An increase in trabecular bone mineral density was observed when comparing mice that had undergone parity once to the nulliparous control. An overall decrease in trabecular bone mineral density was observed as parity increased from 1 to 5 pregnancies. No alteration was seen in cortical bone formation. No difference was observed when calcium, protein and alkaline phosphatase levels were assessed. Conclusions: This study demonstrates that number of parity has an impact on trabecular bone formation in middle-aged mice, with substantial changes in bone density seen among the parous groups.

AB - Objectives: During the reproductive cycle, altered calcium homeostasis is observed due to variable demand for mineral requirements. This results in increased bone resorption during the time period leading up to parturition and subsequent lactation. During lactation, women will lose 1-3% of bone mineral density per month, which is comparable to the loss experienced on an annual basis post-menopausal. The purpose of this study was to determine the effect of parity on bone formation in middle-aged mice. Methods: Mice were mated and grouped by number of parity and compared with age matched nulliparous controls. Measurements were taken of femoral trabecular and cortical bone. Calcium, protein and alkaline phosphatase levels were also measured. Results: An increase in trabecular bone mineral density was observed when comparing mice that had undergone parity once to the nulliparous control. An overall decrease in trabecular bone mineral density was observed as parity increased from 1 to 5 pregnancies. No alteration was seen in cortical bone formation. No difference was observed when calcium, protein and alkaline phosphatase levels were assessed. Conclusions: This study demonstrates that number of parity has an impact on trabecular bone formation in middle-aged mice, with substantial changes in bone density seen among the parous groups.

KW - Cortical bone

KW - Middle age

KW - Multiparity

KW - Multiple gestations

KW - Trabecular bone

UR - http://www.scopus.com/inward/record.url?scp=85037358472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037358472&partnerID=8YFLogxK

M3 - Article

C2 - 29199192

AN - SCOPUS:85037358472

VL - 17

SP - 312

EP - 318

JO - Journal of Musculoskeletal Neuronal Interactions

JF - Journal of Musculoskeletal Neuronal Interactions

SN - 1108-7161

IS - 4

ER -