Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction: Implications for atrial fibrillation

Yasushi Miyauchi, Shengmei Zhou, Yuji Okuyama, Mizuho Miyauchi, Hideki Hayashi, Akira Hamabe, Michael C. Fishbein, William J. Mandel, Lan Chen, Peng-Sheng Chen, Hrayr S. Karagueuzian

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Background - The substrates for the increased incidence of atrial fibrillation (AF) in hearts with chronic left ventricular myocardial infarction (MI) remain poorly defined. We hypothesized that chronic MI is associated with atrial electrical and neural remodeling that enhances AF vulnerability. Methods and Results - We created MI in 8 dogs by permanent occlusion of the left anterior descending (LAD) coronary artery. Seven dogs (3 with thoracotomy) that had no LAD occlusion served as controls. Eight weeks after surgery, the incidence and duration of pacing-induced AF in the open chest anesthetized state were significantly (P

Original languageEnglish (US)
Pages (from-to)360-366
Number of pages7
JournalCirculation
Volume108
Issue number3
DOIs
StatePublished - Jul 22 2003
Externally publishedYes

Fingerprint

Atrial Fibrillation
Myocardial Infarction
Dogs
Atrial Remodeling
Incidence
Thoracotomy
Coronary Vessels
Thorax

Keywords

  • Atrium
  • Fibrillation
  • Myocardial infarction
  • Nervous system
  • Remodeling

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction : Implications for atrial fibrillation. / Miyauchi, Yasushi; Zhou, Shengmei; Okuyama, Yuji; Miyauchi, Mizuho; Hayashi, Hideki; Hamabe, Akira; Fishbein, Michael C.; Mandel, William J.; Chen, Lan; Chen, Peng-Sheng; Karagueuzian, Hrayr S.

In: Circulation, Vol. 108, No. 3, 22.07.2003, p. 360-366.

Research output: Contribution to journalArticle

Miyauchi, Yasushi ; Zhou, Shengmei ; Okuyama, Yuji ; Miyauchi, Mizuho ; Hayashi, Hideki ; Hamabe, Akira ; Fishbein, Michael C. ; Mandel, William J. ; Chen, Lan ; Chen, Peng-Sheng ; Karagueuzian, Hrayr S. / Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction : Implications for atrial fibrillation. In: Circulation. 2003 ; Vol. 108, No. 3. pp. 360-366.
@article{00934a63a7904e17af510c08addd58e9,
title = "Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction: Implications for atrial fibrillation",
abstract = "Background - The substrates for the increased incidence of atrial fibrillation (AF) in hearts with chronic left ventricular myocardial infarction (MI) remain poorly defined. We hypothesized that chronic MI is associated with atrial electrical and neural remodeling that enhances AF vulnerability. Methods and Results - We created MI in 8 dogs by permanent occlusion of the left anterior descending (LAD) coronary artery. Seven dogs (3 with thoracotomy) that had no LAD occlusion served as controls. Eight weeks after surgery, the incidence and duration of pacing-induced AF in the open chest anesthetized state were significantly (P",
keywords = "Atrium, Fibrillation, Myocardial infarction, Nervous system, Remodeling",
author = "Yasushi Miyauchi and Shengmei Zhou and Yuji Okuyama and Mizuho Miyauchi and Hideki Hayashi and Akira Hamabe and Fishbein, {Michael C.} and Mandel, {William J.} and Lan Chen and Peng-Sheng Chen and Karagueuzian, {Hrayr S.}",
year = "2003",
month = "7",
day = "22",
doi = "10.1161/01.CIR.0000080327.32573.7C",
language = "English (US)",
volume = "108",
pages = "360--366",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Altered atrial electrical restitution and heterogeneous sympathetic hyperinnervation in hearts with chronic left ventricular myocardial infarction

T2 - Implications for atrial fibrillation

AU - Miyauchi, Yasushi

AU - Zhou, Shengmei

AU - Okuyama, Yuji

AU - Miyauchi, Mizuho

AU - Hayashi, Hideki

AU - Hamabe, Akira

AU - Fishbein, Michael C.

AU - Mandel, William J.

AU - Chen, Lan

AU - Chen, Peng-Sheng

AU - Karagueuzian, Hrayr S.

PY - 2003/7/22

Y1 - 2003/7/22

N2 - Background - The substrates for the increased incidence of atrial fibrillation (AF) in hearts with chronic left ventricular myocardial infarction (MI) remain poorly defined. We hypothesized that chronic MI is associated with atrial electrical and neural remodeling that enhances AF vulnerability. Methods and Results - We created MI in 8 dogs by permanent occlusion of the left anterior descending (LAD) coronary artery. Seven dogs (3 with thoracotomy) that had no LAD occlusion served as controls. Eight weeks after surgery, the incidence and duration of pacing-induced AF in the open chest anesthetized state were significantly (P

AB - Background - The substrates for the increased incidence of atrial fibrillation (AF) in hearts with chronic left ventricular myocardial infarction (MI) remain poorly defined. We hypothesized that chronic MI is associated with atrial electrical and neural remodeling that enhances AF vulnerability. Methods and Results - We created MI in 8 dogs by permanent occlusion of the left anterior descending (LAD) coronary artery. Seven dogs (3 with thoracotomy) that had no LAD occlusion served as controls. Eight weeks after surgery, the incidence and duration of pacing-induced AF in the open chest anesthetized state were significantly (P

KW - Atrium

KW - Fibrillation

KW - Myocardial infarction

KW - Nervous system

KW - Remodeling

UR - http://www.scopus.com/inward/record.url?scp=0042809557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042809557&partnerID=8YFLogxK

U2 - 10.1161/01.CIR.0000080327.32573.7C

DO - 10.1161/01.CIR.0000080327.32573.7C

M3 - Article

C2 - 12835207

AN - SCOPUS:0042809557

VL - 108

SP - 360

EP - 366

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 3

ER -