Altered baroreceptor function in children with systolic hypertension after coarctation repair

Robert H. Beekman, Barry Katz, Catherine Moorehead-Steffens, Albert P. Rocchini

Research output: Contribution to journalArticle

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Abstract

To determine whether altered baroreceptor function may contribute to systemic hypertension after coarctation of the aorta (C of A) repair, baroreceptor function was evaluated in 6 children with repaired C of A mild arm systolic hypertension. Data were compared with those from 7 normotensive control children with hemodynamically mild heart disease. Age at C of A repair averaged 9.9 ± 3.1 years (mean ± standard deviation [SD]). Arm systolic pressure was 143.8 ± 2.9 mm Hg in the C of A repair group, compared with 118.3 ± 9.9 for control subjects (p <0.001). At catheterization, steady-state sigmoidal baroreceptor function curves relating mean arterial pressure to R-R interval were derived by increasing and decreasing mean arterial pressure with small injections of phenylephrine and nitroprusside. Compared with control subjects, the baroreceptor function curves of children with repaired C of A (1) are reset about a higher baseline mean arterial pressure (108.8 ± 6.6 versus 90.3 ± 8.6 mm Hg, p <0.01), (2) have a decreased slope (7.9 ± 3.7 versus 17.4 ± 3.6 ms/mm Hg, p <0.001), and (3) have a diminished R-R interval range (246.7 ± 81.5 versus 535.7 ± 97.2 ms, p <0.001). Thus, in children with hypertension after C of A repair, the baroreflex is reset to an elevated mean arterial pressure level and has a diminished sensitivity to changes in arterial pressure.

Original languageEnglish (US)
Pages (from-to)112-117
Number of pages6
JournalThe American Journal of Cardiology
Volume52
Issue number1
DOIs
StatePublished - 1983
Externally publishedYes

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Pressoreceptors
Arterial Pressure
Hypertension
Aortic Coarctation
Baroreflex
Nitroprusside
Phenylephrine
Catheterization
Heart Diseases
Blood Pressure
Injections

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Altered baroreceptor function in children with systolic hypertension after coarctation repair. / Beekman, Robert H.; Katz, Barry; Moorehead-Steffens, Catherine; Rocchini, Albert P.

In: The American Journal of Cardiology, Vol. 52, No. 1, 1983, p. 112-117.

Research output: Contribution to journalArticle

Beekman, Robert H. ; Katz, Barry ; Moorehead-Steffens, Catherine ; Rocchini, Albert P. / Altered baroreceptor function in children with systolic hypertension after coarctation repair. In: The American Journal of Cardiology. 1983 ; Vol. 52, No. 1. pp. 112-117.
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