Altered expression of insulin-like growth factor II receptor in human pancreatic cancer

Toshiyuki Ishiwata, Uwe Bergmann, Marko Kornmann, Martha Lopez, Hans G. Beger, Murray Korc

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The insulin-like growth factor-II (IGF-II) receptor (IGF-IIR) is a single-chain transmembrane protein identical to the mannose-6-phosphate receptor. In the present study we examined IGF-IIR expression in normal and cancerous human pancreatic tissues. In the normal pancreas, moderately strong IGF-IIR immunoreactivity was present in the cytoplasm of islet cells, and mild cytoplasmic immunoreactivity was evident occasionally in ductal and acinar cells. Some ductal cells also exhibited nuclear IGF-IIR immunoreactivity. In the pancreatic cancers, regions of strong IGF-IIR immunoreactivity were present in the duct-like cancer cells within the tumor mass, often exhibiting nuclear localization. Expression of IGF-IIR mRNA in the cancer cells was confirmed by in situ hybridization. By comparison with normal pancreatic tissues, 7 of 12 pancreatic cancers exhibited a 5.6-fold increase in IGF-IIR mRNA levels, whereas in 3 cancers the IGF-IIR transcript was below the level of detection. Furthermore, all six tested cultured human pancreatic cancer cell lines expressed the IGF-IIR mRNA transcript. Our data indicate that IGF-IIR is overexpressed in a significant number of human pancreatic cancers, where it has a tendency to localize in the nucleus, and raise the possibility that IGF-IIR may contribute to the pathobiology of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalPancreas
Volume15
Issue number4
DOIs
StatePublished - Nov 1997

Keywords

  • Altered expression
  • Human pancreatic cancer
  • Insulin-like growth factor II receptor

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Fingerprint Dive into the research topics of 'Altered expression of insulin-like growth factor II receptor in human pancreatic cancer'. Together they form a unique fingerprint.

  • Cite this

    Ishiwata, T., Bergmann, U., Kornmann, M., Lopez, M., Beger, H. G., & Korc, M. (1997). Altered expression of insulin-like growth factor II receptor in human pancreatic cancer. Pancreas, 15(4), 367-373. https://doi.org/10.1097/00006676-199711000-00006