Altered microRNA expression following traumatic spinal cord injury

Nai Kui Liu, Xiao Fei Wang, Qing Bo Lu, Xiao Ming Xu

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are a novel class of small non-coding RNAs that negatively regulate gene expression at the posttranscriptional level by binding to the 3′ untranslated region of target mRNAs leading to their translational inhibition or sometimes degradation. We uncovered a previously unknown alteration in temporal expression of a large set of miRNAs following a contusive spinal cord injury (SCI) in adult rats using microarray analysis. These altered miRNAs can be classified into 3 categories: (1) up-regulation, (2) down-regulation and (3) an early up-regulation at 4 h followed by down-regulation at 1 and 7 days post-SCI. The bioinformatics analysis indicates that the potential targets for miRNAs altered after SCI include genes encoding components that are involved in the inflammation, oxidation, and apoptosis that are known to play important roles in the pathogenesis of SCI. These findings suggest that abnormal expression of miRNAs may contribute to the pathogenesis of SCI and are potential targets for therapeutic interventions following SCI.

Original languageEnglish
Pages (from-to)424-429
Number of pages6
JournalExperimental Neurology
Volume219
Issue number2
DOIs
StatePublished - Oct 2009

Fingerprint

MicroRNAs
Spinal Cord Injuries
Up-Regulation
Down-Regulation
Gene Components
Small Untranslated RNA
3' Untranslated Regions
Microarray Analysis
Computational Biology
Apoptosis
Inflammation
Gene Expression
Messenger RNA

Keywords

  • Apoptosis
  • Gene expression
  • Inflammation
  • MicroRNA
  • Oxidation
  • Spinal cord injury

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Cite this

Altered microRNA expression following traumatic spinal cord injury. / Liu, Nai Kui; Wang, Xiao Fei; Lu, Qing Bo; Xu, Xiao Ming.

In: Experimental Neurology, Vol. 219, No. 2, 10.2009, p. 424-429.

Research output: Contribution to journalArticle

Liu, Nai Kui ; Wang, Xiao Fei ; Lu, Qing Bo ; Xu, Xiao Ming. / Altered microRNA expression following traumatic spinal cord injury. In: Experimental Neurology. 2009 ; Vol. 219, No. 2. pp. 424-429.
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