Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

Olga Kokiko-Cochran, Lena Ransohoff, Mike Veenstra, Sungho Lee, Maha Saber, Matt Sikora, Ryan Teknipp, Guixiang Xu, Shane Bemiller, Gina Wilson, Samuel Crish, Kiran Bhaskar, Yu Shang Lee, Richard M. Ransohoff, Bruce Lamb

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) has acute and chronic sequelae, including an increased risk for the development of Alzheimer's disease (AD). TBI-associated neuroinflammation is characterized by activation of brain-resident microglia and infiltration of monocytes; however, recent studies have implicated beta-amyloid as a major manipulator of the inflammatory response. To examine neuroinflammation after TBI and development of AD-like features, these studies examined the effects of TBI in the presence and absence of beta-amyloid. The R1.40 mouse model of cerebral amyloidosis was used, with a focus on time points well before robust AD pathologies. Unexpectedly, in R1.40 mice, the acute neuroinflammatory response to TBI was strikingly muted, with reduced numbers of CNS myeloid cells acquiring a macrophage phenotype and decreased expression of inflammatory cytokines. At chronic time points, macrophage activation substantially declined in non-Tg TBI mice; however, it was relatively unchanged in R1.40 TBI mice. The persistent inflammatory response coincided with significant tissue loss between 3 and 120 days post-injury in R1.40 TBI mice, which was not observed in non-Tg TBI mice. Surprisingly, inflammatory cytokine expression was enhanced in R1.40 mice compared with non-Tg mice, regardless of injury group. Although R1.40 TBI mice demonstrated task-specific deficits in cognition, overall functional recovery was similar to non-Tg TBI mice. These findings suggest that accumulating beta-amyloid leads to an altered post-injury macrophage response at acute and chronic time points. Together, these studies emphasize the role of post-injury neuroinflammation in regulating long-term sequelae after TBI and also support recent studies implicating beta-amyloid as an immunomodulator.

Original languageEnglish (US)
Pages (from-to)625-640
Number of pages16
JournalJournal of Neurotrauma
Volume33
Issue number7
DOIs
StatePublished - Apr 1 2016
Externally publishedYes

Fingerprint

Alzheimer Disease
Amyloid
Wounds and Injuries
Traumatic Brain Injury
Macrophages
Cytokines
Macrophage Activation
Immunologic Factors
Microglia
Myeloid Cells
Cognition
Monocytes
Pathology
Phenotype
Brain

Keywords

  • Alzheimer's disease
  • macrophage
  • neuroinflammation
  • traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease. / Kokiko-Cochran, Olga; Ransohoff, Lena; Veenstra, Mike; Lee, Sungho; Saber, Maha; Sikora, Matt; Teknipp, Ryan; Xu, Guixiang; Bemiller, Shane; Wilson, Gina; Crish, Samuel; Bhaskar, Kiran; Lee, Yu Shang; Ransohoff, Richard M.; Lamb, Bruce.

In: Journal of Neurotrauma, Vol. 33, No. 7, 01.04.2016, p. 625-640.

Research output: Contribution to journalArticle

Kokiko-Cochran, O, Ransohoff, L, Veenstra, M, Lee, S, Saber, M, Sikora, M, Teknipp, R, Xu, G, Bemiller, S, Wilson, G, Crish, S, Bhaskar, K, Lee, YS, Ransohoff, RM & Lamb, B 2016, 'Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease', Journal of Neurotrauma, vol. 33, no. 7, pp. 625-640. https://doi.org/10.1089/neu.2015.3970
Kokiko-Cochran, Olga ; Ransohoff, Lena ; Veenstra, Mike ; Lee, Sungho ; Saber, Maha ; Sikora, Matt ; Teknipp, Ryan ; Xu, Guixiang ; Bemiller, Shane ; Wilson, Gina ; Crish, Samuel ; Bhaskar, Kiran ; Lee, Yu Shang ; Ransohoff, Richard M. ; Lamb, Bruce. / Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease. In: Journal of Neurotrauma. 2016 ; Vol. 33, No. 7. pp. 625-640.
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