Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain

Angelica Becaria, Debomoy Lahiri, Stephen C. Bondy, DeMao Chen, Ali Hamadeh, Huihui Li, Russell Taylor, Arezoo Campbell

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Inflammatory and oxidative events are up-regulated in the brain of AD patients. It has been reported that in animal models of AD, exposure to aluminum (Al) or copper (Cu) enhanced oxidative events and accumulation of amyloid beta (Aβ) peptides. The present study was designed to evaluate the effect of a 3-month exposure of mice to copper sulfate (8 μM), aluminum lactate (10 or 100 μM), or a combination of the salts. Results suggest that although Al or Cu may independently initiate inflammatory or oxidative events, they may function cooperatively to increase APP levels.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalJournal of Neuroimmunology
Volume176
Issue number1-2
DOIs
StatePublished - Jul 2006

Fingerprint

Aluminum
Drinking Water
Copper
Copper Sulfate
Amyloid beta-Peptides
Brain
Animal Models
Salts
aluminum lactate

Keywords

  • Aluminum
  • Alzheimer's disease
  • Amyloid beta
  • Copper
  • Neuroinflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain. / Becaria, Angelica; Lahiri, Debomoy; Bondy, Stephen C.; Chen, DeMao; Hamadeh, Ali; Li, Huihui; Taylor, Russell; Campbell, Arezoo.

In: Journal of Neuroimmunology, Vol. 176, No. 1-2, 07.2006, p. 16-23.

Research output: Contribution to journalArticle

Becaria, Angelica ; Lahiri, Debomoy ; Bondy, Stephen C. ; Chen, DeMao ; Hamadeh, Ali ; Li, Huihui ; Taylor, Russell ; Campbell, Arezoo. / Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain. In: Journal of Neuroimmunology. 2006 ; Vol. 176, No. 1-2. pp. 16-23.
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