Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain

Angelica Becaria, Debomoy K. Lahiri, Stephen C. Bondy, De Mao Chen, Ali Hamadeh, Huihui Li, Russell Taylor, Arezoo Campbell

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

Inflammatory and oxidative events are up-regulated in the brain of AD patients. It has been reported that in animal models of AD, exposure to aluminum (Al) or copper (Cu) enhanced oxidative events and accumulation of amyloid beta (Aβ) peptides. The present study was designed to evaluate the effect of a 3-month exposure of mice to copper sulfate (8 μM), aluminum lactate (10 or 100 μM), or a combination of the salts. Results suggest that although Al or Cu may independently initiate inflammatory or oxidative events, they may function cooperatively to increase APP levels.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalJournal of Neuroimmunology
Volume176
Issue number1-2
DOIs
StatePublished - Jul 1 2006

Keywords

  • Aluminum
  • Alzheimer's disease
  • Amyloid beta
  • Copper
  • Neuroinflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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