Aluminum bone disease in children: Radiographic features from diagnosis to resolution

S. P. Andreoli, J. A. Smith, J. M. Bergstein

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Two children with chronic renal failure developed aluminum intoxication as a result of long-term ingestion of aluminum hydroxide for the control of hyperphosphatemia. In each child, bone biopsy confirmed severe osteomalacia, the absence of features of hyperparathyroid bone disease, and massive aluminum deposition at the bone-osteoid junction. Radiographs during the period of aluminum intoxication demonstrated osteopenia, pathologic fractures, fraying of the metaphyses of the long bones, and widening of the physis. When aluminum hydroxide therapy was discontinued (each patient) and aluminum was removed with chelation therapy (one patient), radiographs demonstrated a distinctly unusual pattern of healing. Calcification of the long bones began at the most recently formed osteoid and then proceeded toward the diaphysis. This unusual healing pattern created lucent defects and a transient 'bone within a bone' appearance, which resolved with further healing.

Original languageEnglish (US)
Pages (from-to)663-667
Number of pages5
JournalRadiology
Volume156
Issue number3
DOIs
StatePublished - Jan 1 1985

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Bone Diseases
Aluminum
Bone and Bones
Aluminum Hydroxide
Chelation Therapy
Hyperphosphatemia
Diaphyses
Osteomalacia
Spontaneous Fractures
Metabolic Bone Diseases
Chronic Kidney Failure
Eating
Biopsy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Aluminum bone disease in children : Radiographic features from diagnosis to resolution. / Andreoli, S. P.; Smith, J. A.; Bergstein, J. M.

In: Radiology, Vol. 156, No. 3, 01.01.1985, p. 663-667.

Research output: Contribution to journalArticle

Andreoli, S. P. ; Smith, J. A. ; Bergstein, J. M. / Aluminum bone disease in children : Radiographic features from diagnosis to resolution. In: Radiology. 1985 ; Vol. 156, No. 3. pp. 663-667.
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