Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

Cristian A. Lasagna-Reeves, Diana L. Castillo-Carranza, Urmi Sengupta, Marcos J. Guerrero-Munoz, Takaki Kiritoshi, Volker Neugebauer, George R. Jackson, Rakez Kayed

Research output: Contribution to journalArticlepeer-review

244 Scopus citations

Abstract

Intracerebral injection of brain extracts containing amyloid or tau aggregates in transgenic animals can induce cerebral amyloidosis and tau pathology. We extracted pure populations of tau oligomers directly from the cerebral cortex of Alzheimer disease (AD) brain. These oligomers are potent inhibitors of long term potentiation (LTP) in hippocampal brain slices and disrupt memory in wild type mice. We observed for the first time that these authentic brain-derived tau oligomers propagate abnormal tau conformation of endogenous murine tau after prolonged incubation. The conformation and hydrophobicity of tau oligomers play a critical role in the initiation and spread of tau pathology in the naïve host in a manner reminiscent of sporadic AD.

Original languageEnglish (US)
Article number700
JournalScientific reports
Volume2
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • General

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