Alzheimer patients and Down patients: Abnormal presynaptic terminals are related to cerebral preamyloid deposits

Orso Bugiani, Giorgio Giaccone, Laura Verga, Bianca Pollo, Bernardino Ghetti, Blas Frangione, Fabrizio Tagliavini

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

In Alzheimer's disease, in Down syndrome and in normal aging, scattered deposits of amyloid fibril precursors occur in both cerebral cortex and subcortical grey structures. Within such preamyloid deposits, no degenerating neurites with paired helical filaments have ever been observed. This study, carried out on brains from Alzheimer patients and Down patients, reports on the relationship between preamyloid deposits and neuritic changes. These changes were represented by presynaptic terminal swellings immunolabeled by antisynaptophysin and antiubiquitin antibodies, not by Alz50. These findings support the view that the deposition of amyloid fibril precursors in the neuropil is closely related to presynaptic terminals, although whether the former precedes or follows the development of presynaptic terminal changes is still undetermined.

Original languageEnglish (US)
Pages (from-to)56-59
Number of pages4
JournalNeuroscience Letters
Volume119
Issue number1
DOIs
StatePublished - Oct 30 1990

Keywords

  • Alzheimer's desease
  • Amyloid
  • Down syndrome
  • Synapse

ASJC Scopus subject areas

  • Neuroscience(all)

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