Alzheimer patients: preamyloid deposits are more widely distributed than senile plaques throughout the central nervous system

Orso Bugiani, Giorgio Giaccone, Blas Frangione, Bernardino Ghetti, Fabrizio Tagliavini

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

In Alzheimer's disease, anti-β-protein antisera label not only amyloid deposits accompanied by degenerating neurites (neuritic and mature plaques) and amyloid deposits without degenerating neurites, but also preamyloid deposits lacking the optical properties of amyloid fibrils. We have carried out a study of the brains of 13 patients with Alzheimer's disease (one with the familial and 12 with the sporadic form), using anti-β-protein and anti-paired helical filament antisera, thioflavine S, Congo red and Gallyas' silver impregnation, in order to determine whether the distribution of preamyloid deposits and amyloid deposits without degenerating neurites differs from that of amyloid deposits with degenerating neurites. Preamyloid deposits and amyloid deposits with or without degenerating neurites were present in cortex, neostriatum, medial geniculate body and thalamic (anterior and extralaminar) nuclei, whereas preamyloid deposits and amyloid deposits without degenerating neurites, but not amyloid deposits with degenerating neurites, were present in other thalamic nuclei, in the globus pallidus, brainstem, cerebellar cortex and upper spinal cord. These results support the view that preamyloid deposits evolve to senile (neuritic and mature) plaques only in specific brain regions, where neurites vulnerable to amyloid fibrils are widely distributed.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalNeuroscience Letters
Volume103
Issue number3
DOIs
StatePublished - Sep 11 1989

Fingerprint

Amyloid Plaques
Central Nervous System
Amyloid
Immune Sera
Alzheimer Disease
Anterior Thalamic Nuclei
Geniculate Bodies
Neostriatum
Congo Red
Thalamic Nuclei
Cerebellar Cortex
Globus Pallidus
Brain
Silver
Brain Stem

Keywords

  • Alzheimer's disease
  • Amyloid
  • Immunocytochemistry
  • Senile plaque

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alzheimer patients : preamyloid deposits are more widely distributed than senile plaques throughout the central nervous system. / Bugiani, Orso; Giaccone, Giorgio; Frangione, Blas; Ghetti, Bernardino; Tagliavini, Fabrizio.

In: Neuroscience Letters, Vol. 103, No. 3, 11.09.1989, p. 263-268.

Research output: Contribution to journalArticle

Bugiani, Orso ; Giaccone, Giorgio ; Frangione, Blas ; Ghetti, Bernardino ; Tagliavini, Fabrizio. / Alzheimer patients : preamyloid deposits are more widely distributed than senile plaques throughout the central nervous system. In: Neuroscience Letters. 1989 ; Vol. 103, No. 3. pp. 263-268.
@article{d0eba114245e4c169fa7d28de733e5af,
title = "Alzheimer patients: preamyloid deposits are more widely distributed than senile plaques throughout the central nervous system",
abstract = "In Alzheimer's disease, anti-β-protein antisera label not only amyloid deposits accompanied by degenerating neurites (neuritic and mature plaques) and amyloid deposits without degenerating neurites, but also preamyloid deposits lacking the optical properties of amyloid fibrils. We have carried out a study of the brains of 13 patients with Alzheimer's disease (one with the familial and 12 with the sporadic form), using anti-β-protein and anti-paired helical filament antisera, thioflavine S, Congo red and Gallyas' silver impregnation, in order to determine whether the distribution of preamyloid deposits and amyloid deposits without degenerating neurites differs from that of amyloid deposits with degenerating neurites. Preamyloid deposits and amyloid deposits with or without degenerating neurites were present in cortex, neostriatum, medial geniculate body and thalamic (anterior and extralaminar) nuclei, whereas preamyloid deposits and amyloid deposits without degenerating neurites, but not amyloid deposits with degenerating neurites, were present in other thalamic nuclei, in the globus pallidus, brainstem, cerebellar cortex and upper spinal cord. These results support the view that preamyloid deposits evolve to senile (neuritic and mature) plaques only in specific brain regions, where neurites vulnerable to amyloid fibrils are widely distributed.",
keywords = "Alzheimer's disease, Amyloid, Immunocytochemistry, Senile plaque",
author = "Orso Bugiani and Giorgio Giaccone and Blas Frangione and Bernardino Ghetti and Fabrizio Tagliavini",
year = "1989",
month = "9",
day = "11",
doi = "10.1016/0304-3940(89)90110-9",
language = "English",
volume = "103",
pages = "263--268",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Alzheimer patients

T2 - preamyloid deposits are more widely distributed than senile plaques throughout the central nervous system

AU - Bugiani, Orso

AU - Giaccone, Giorgio

AU - Frangione, Blas

AU - Ghetti, Bernardino

AU - Tagliavini, Fabrizio

PY - 1989/9/11

Y1 - 1989/9/11

N2 - In Alzheimer's disease, anti-β-protein antisera label not only amyloid deposits accompanied by degenerating neurites (neuritic and mature plaques) and amyloid deposits without degenerating neurites, but also preamyloid deposits lacking the optical properties of amyloid fibrils. We have carried out a study of the brains of 13 patients with Alzheimer's disease (one with the familial and 12 with the sporadic form), using anti-β-protein and anti-paired helical filament antisera, thioflavine S, Congo red and Gallyas' silver impregnation, in order to determine whether the distribution of preamyloid deposits and amyloid deposits without degenerating neurites differs from that of amyloid deposits with degenerating neurites. Preamyloid deposits and amyloid deposits with or without degenerating neurites were present in cortex, neostriatum, medial geniculate body and thalamic (anterior and extralaminar) nuclei, whereas preamyloid deposits and amyloid deposits without degenerating neurites, but not amyloid deposits with degenerating neurites, were present in other thalamic nuclei, in the globus pallidus, brainstem, cerebellar cortex and upper spinal cord. These results support the view that preamyloid deposits evolve to senile (neuritic and mature) plaques only in specific brain regions, where neurites vulnerable to amyloid fibrils are widely distributed.

AB - In Alzheimer's disease, anti-β-protein antisera label not only amyloid deposits accompanied by degenerating neurites (neuritic and mature plaques) and amyloid deposits without degenerating neurites, but also preamyloid deposits lacking the optical properties of amyloid fibrils. We have carried out a study of the brains of 13 patients with Alzheimer's disease (one with the familial and 12 with the sporadic form), using anti-β-protein and anti-paired helical filament antisera, thioflavine S, Congo red and Gallyas' silver impregnation, in order to determine whether the distribution of preamyloid deposits and amyloid deposits without degenerating neurites differs from that of amyloid deposits with degenerating neurites. Preamyloid deposits and amyloid deposits with or without degenerating neurites were present in cortex, neostriatum, medial geniculate body and thalamic (anterior and extralaminar) nuclei, whereas preamyloid deposits and amyloid deposits without degenerating neurites, but not amyloid deposits with degenerating neurites, were present in other thalamic nuclei, in the globus pallidus, brainstem, cerebellar cortex and upper spinal cord. These results support the view that preamyloid deposits evolve to senile (neuritic and mature) plaques only in specific brain regions, where neurites vulnerable to amyloid fibrils are widely distributed.

KW - Alzheimer's disease

KW - Amyloid

KW - Immunocytochemistry

KW - Senile plaque

UR - http://www.scopus.com/inward/record.url?scp=0024358846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024358846&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(89)90110-9

DO - 10.1016/0304-3940(89)90110-9

M3 - Article

C2 - 2478933

AN - SCOPUS:0024358846

VL - 103

SP - 263

EP - 268

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -