Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding

Andreas Lazaris, Kristy S. Hwang, Naira Goukasian, Leslie M. Ramirez, Jennifer Eastman, Anna E. Blanken, Edmond Teng, Karen Gylys, Greg Cole, Andrew Saykin, Leslie M. Shaw, John Q. Trojanowski, William J. Jagust, Michael W. Weiner, Liana G. Apostolova

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: We investigated the association between apoE protein plasma levels and brain amyloidosis and the effect of the top 10 Alzheimer disease (AD) risk genes on this association. Methods: Our dataset consisted of 18 AD, 52 mild cognitive impairment, and 3 cognitively normal Alzheimer's Disease Neuroimaging Initiative 1 (ADNI1) participants with available [11C]-Pittsburgh compound B (PiB) and peripheral blood protein data. We used cortical pattern matching to study associations between plasma apoE and cortical PiB binding and the effect of carrier status for the top 10 AD risk genes. Results: Low plasma apoE was significantly associated with high PiB SUVR, except in the sensorimotor and entorhinal cortex. For BIN1 rs744373, the association was observed only in minor allele carriers. For CD2AP rs9349407 and CR1 rs3818361, the association was preservedonly in minor allele noncarriers. We did not find evidence for modulation by CLU, PICALM, ABCA7, BIN1, and MS4A6A. Conclusions: Our data show that BIN1 rs744373, CD2AP rs9349407, and CR1 rs3818361 genotypes modulate the association between apoE protein plasma levels and brain amyloidosis, implying a potential epigenetic/downstream interaction.

Original languageEnglish (US)
Article numbere22
JournalNeurology: Genetics
Volume1
Issue number3
DOIs
StatePublished - Oct 1 2015

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Apolipoproteins E
Blood Proteins
Amyloidosis
Genes
Alzheimer Disease
Alleles
Entorhinal Cortex
Brain
Epigenomics
Neuroimaging
Genotype
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Alzheimer Disease 10

ASJC Scopus subject areas

  • Clinical Neurology
  • Genetics(clinical)

Cite this

Lazaris, A., Hwang, K. S., Goukasian, N., Ramirez, L. M., Eastman, J., Blanken, A. E., ... Apostolova, L. G. (2015). Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding. Neurology: Genetics, 1(3), [e22]. https://doi.org/10.1212/NXG.0000000000000022

Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding. / Lazaris, Andreas; Hwang, Kristy S.; Goukasian, Naira; Ramirez, Leslie M.; Eastman, Jennifer; Blanken, Anna E.; Teng, Edmond; Gylys, Karen; Cole, Greg; Saykin, Andrew; Shaw, Leslie M.; Trojanowski, John Q.; Jagust, William J.; Weiner, Michael W.; Apostolova, Liana G.

In: Neurology: Genetics, Vol. 1, No. 3, e22, 01.10.2015.

Research output: Contribution to journalArticle

Lazaris, A, Hwang, KS, Goukasian, N, Ramirez, LM, Eastman, J, Blanken, AE, Teng, E, Gylys, K, Cole, G, Saykin, A, Shaw, LM, Trojanowski, JQ, Jagust, WJ, Weiner, MW & Apostolova, LG 2015, 'Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding', Neurology: Genetics, vol. 1, no. 3, e22. https://doi.org/10.1212/NXG.0000000000000022
Lazaris, Andreas ; Hwang, Kristy S. ; Goukasian, Naira ; Ramirez, Leslie M. ; Eastman, Jennifer ; Blanken, Anna E. ; Teng, Edmond ; Gylys, Karen ; Cole, Greg ; Saykin, Andrew ; Shaw, Leslie M. ; Trojanowski, John Q. ; Jagust, William J. ; Weiner, Michael W. ; Apostolova, Liana G. / Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding. In: Neurology: Genetics. 2015 ; Vol. 1, No. 3.
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AU - Blanken, Anna E.

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