Alzheimer's disease: Clinical implications of the apolipoprotein E genotype

Research output: Contribution to journalArticle

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Abstract

Inheritance of the apolipoprotein E (APOE = gene; apoE = protein) ε4 gene is associated with a higher risk for development of Alzheimer's disease (AD) and for occurrence of this illness at a younger age. APOE gene dose and genotype interact with gender, ethnicity, and age to influence the probability of developing AD, as well as the rate of disease progression. The sensitivity and specificity of APOE genotyping, however, and the longer-term implications of the ε4 allele as a susceptibility factor for AD, are not yet adequately understood to recommend the use of APOE genotyping in genetic counseling of asymptomatic family members of AD patients. Insufficient evidence also exists at this time to recommend APOE genotyping as an adjuvant for the differential diagnosis of dementia or as a possible predictor for response to drug therapy. These potential future clinical indications for apoE genotyping are under active investigation.

Original languageEnglish
JournalNeurology
Volume48
Issue number5 SUPPL. 6
StatePublished - May 1997

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Apolipoproteins E
Alzheimer Disease
Genotype
Genetic Counseling
Genes
Dementia
Disease Progression
Differential Diagnosis
Alleles
Drug Therapy
Sensitivity and Specificity
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alzheimer's disease : Clinical implications of the apolipoprotein E genotype. / Farlow, Martin.

In: Neurology, Vol. 48, No. 5 SUPPL. 6, 05.1997.

Research output: Contribution to journalArticle

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