Ambulatory patients with spina bifida are 50% more likely to be fecally continent than non-ambulatory patients, particularly after a MACE procedure

T. Large, Konrad Szymanski, Benjamin Whittam, R. Misseri, Katherine Chan, Martin Kaefer, R. C. Rink, M. P. Cain

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: While fecal incontinence (FI) affects many patients with spina bifida (SB), it is unclear if it is associated with ambulatory status. Objective: To determine if ambulatory status is associated with FI, and a potential confounding variable, in patients with and without a Malone antegrade continence enema (MACE). Study design: This study retrospectively reviewed of patients aged ≥8 years with SB who were enrolled in an international quality of life study at outpatient visits (January 2013 to September 2015). Patients reported FI over the last 4 weeks (strict criteria: any FI/accidents vs no FI). Patients unable to self-report FI due to developmental delay were excluded. Those who were ambulating outdoors with/without braces/crutches were considered community ambulators. Non-parametric tests and logistic regression were used for analysis. Results: A total of 115 patients with a MACE and 57 without a MACE were similar in gender (P = 0.99), ventriculoperitoneal status (P = 0.15) and age (16.0 vs 15.4 years, . P = 0.11). Median ages at MACE procedure and follow-up were 7.0 and 8.2 years, respectively, and all used the MACE ≥3x/week. They were less likely to be ambulators (54.8 vs 71.9%, . P = 0.03). In patients with a MACE, 64 (55.7%) had total fecal continence, compared with 29 (50.9%) without a MACE (P = 0.62). In the MACE group, ambulators were more likely to be continent compared with non-ambulatory patients (65.1 vs 44.2%, . P = 0.04) (Table). Although not statistically significant, a similar difference was observed in the non-MACE group (56.1 vs 37.5%, . P = 0.25). In the MACE group, continent and incontinent patients, regardless of ambulatory status, had similar rates of MACE use, additive use and time for MACE completion (P ≥ 0.43). MACE ambulators were more likely to be continent than MACE non-ambulators on multivariate analysis (OR 3.26, . P = 0.01). Discussion: This study reported higher than typical FI rates since: (1) it used a stringent definition of total fecal continence; (2) patients without FI were perhaps less likely to participate; and (3) it relied on patient-reported rather than clinician-reported outcomes. This cross-sectional study should not be interpreted as MACE procedure is ineffective; this would require a longitudinal study. The present findings may not apply to young children or those with significant developmental delay (patients excluded from the study). Conclusions: Ambulatory patients with SB are 50% more likely to have total fecal continence on long-term follow-up, particularly after a MACE procedure. Ambulatory status is a significant confounder of FI and should be considered in future analyses.Summary tablePredictors of fecal continence after MACE procedure.Summary tablePatient characteristicNo MACE (n = 57)MACE (n = 115)Non-ambulatory6/16 (37.5%)23/52 (44.2%)Ambulatory23/41 (56.1%)41/63 (65.1%) P-value0.250.04MACE, Malone antegrade continence enema. . .

Original languageEnglish (US)
JournalJournal of Pediatric Urology
DOIs
StateAccepted/In press - Apr 29 2016

Fingerprint

Spinal Dysraphism
Enema
Fecal Incontinence
Crutches
Braces

Keywords

  • Ambulation
  • Fecal incontinence
  • Malone antegrade continence enema
  • Spina bifida

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Urology

Cite this

@article{0bf051ba6bf94055b4a4ba8f4ea3f504,
title = "Ambulatory patients with spina bifida are 50{\%} more likely to be fecally continent than non-ambulatory patients, particularly after a MACE procedure",
abstract = "Introduction: While fecal incontinence (FI) affects many patients with spina bifida (SB), it is unclear if it is associated with ambulatory status. Objective: To determine if ambulatory status is associated with FI, and a potential confounding variable, in patients with and without a Malone antegrade continence enema (MACE). Study design: This study retrospectively reviewed of patients aged ≥8 years with SB who were enrolled in an international quality of life study at outpatient visits (January 2013 to September 2015). Patients reported FI over the last 4 weeks (strict criteria: any FI/accidents vs no FI). Patients unable to self-report FI due to developmental delay were excluded. Those who were ambulating outdoors with/without braces/crutches were considered community ambulators. Non-parametric tests and logistic regression were used for analysis. Results: A total of 115 patients with a MACE and 57 without a MACE were similar in gender (P = 0.99), ventriculoperitoneal status (P = 0.15) and age (16.0 vs 15.4 years, . P = 0.11). Median ages at MACE procedure and follow-up were 7.0 and 8.2 years, respectively, and all used the MACE ≥3x/week. They were less likely to be ambulators (54.8 vs 71.9{\%}, . P = 0.03). In patients with a MACE, 64 (55.7{\%}) had total fecal continence, compared with 29 (50.9{\%}) without a MACE (P = 0.62). In the MACE group, ambulators were more likely to be continent compared with non-ambulatory patients (65.1 vs 44.2{\%}, . P = 0.04) (Table). Although not statistically significant, a similar difference was observed in the non-MACE group (56.1 vs 37.5{\%}, . P = 0.25). In the MACE group, continent and incontinent patients, regardless of ambulatory status, had similar rates of MACE use, additive use and time for MACE completion (P ≥ 0.43). MACE ambulators were more likely to be continent than MACE non-ambulators on multivariate analysis (OR 3.26, . P = 0.01). Discussion: This study reported higher than typical FI rates since: (1) it used a stringent definition of total fecal continence; (2) patients without FI were perhaps less likely to participate; and (3) it relied on patient-reported rather than clinician-reported outcomes. This cross-sectional study should not be interpreted as MACE procedure is ineffective; this would require a longitudinal study. The present findings may not apply to young children or those with significant developmental delay (patients excluded from the study). Conclusions: Ambulatory patients with SB are 50{\%} more likely to have total fecal continence on long-term follow-up, particularly after a MACE procedure. Ambulatory status is a significant confounder of FI and should be considered in future analyses.Summary tablePredictors of fecal continence after MACE procedure.Summary tablePatient characteristicNo MACE (n = 57)MACE (n = 115)Non-ambulatory6/16 (37.5{\%})23/52 (44.2{\%})Ambulatory23/41 (56.1{\%})41/63 (65.1{\%}) P-value0.250.04MACE, Malone antegrade continence enema. . .",
keywords = "Ambulation, Fecal incontinence, Malone antegrade continence enema, Spina bifida",
author = "T. Large and Konrad Szymanski and Benjamin Whittam and R. Misseri and Katherine Chan and Martin Kaefer and Rink, {R. C.} and Cain, {M. P.}",
year = "2016",
month = "4",
day = "29",
doi = "10.1016/j.jpurol.2016.06.019",
language = "English (US)",
journal = "Journal of Pediatric Urology",
issn = "1477-5131",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Ambulatory patients with spina bifida are 50% more likely to be fecally continent than non-ambulatory patients, particularly after a MACE procedure

AU - Large, T.

AU - Szymanski, Konrad

AU - Whittam, Benjamin

AU - Misseri, R.

AU - Chan, Katherine

AU - Kaefer, Martin

AU - Rink, R. C.

AU - Cain, M. P.

PY - 2016/4/29

Y1 - 2016/4/29

N2 - Introduction: While fecal incontinence (FI) affects many patients with spina bifida (SB), it is unclear if it is associated with ambulatory status. Objective: To determine if ambulatory status is associated with FI, and a potential confounding variable, in patients with and without a Malone antegrade continence enema (MACE). Study design: This study retrospectively reviewed of patients aged ≥8 years with SB who were enrolled in an international quality of life study at outpatient visits (January 2013 to September 2015). Patients reported FI over the last 4 weeks (strict criteria: any FI/accidents vs no FI). Patients unable to self-report FI due to developmental delay were excluded. Those who were ambulating outdoors with/without braces/crutches were considered community ambulators. Non-parametric tests and logistic regression were used for analysis. Results: A total of 115 patients with a MACE and 57 without a MACE were similar in gender (P = 0.99), ventriculoperitoneal status (P = 0.15) and age (16.0 vs 15.4 years, . P = 0.11). Median ages at MACE procedure and follow-up were 7.0 and 8.2 years, respectively, and all used the MACE ≥3x/week. They were less likely to be ambulators (54.8 vs 71.9%, . P = 0.03). In patients with a MACE, 64 (55.7%) had total fecal continence, compared with 29 (50.9%) without a MACE (P = 0.62). In the MACE group, ambulators were more likely to be continent compared with non-ambulatory patients (65.1 vs 44.2%, . P = 0.04) (Table). Although not statistically significant, a similar difference was observed in the non-MACE group (56.1 vs 37.5%, . P = 0.25). In the MACE group, continent and incontinent patients, regardless of ambulatory status, had similar rates of MACE use, additive use and time for MACE completion (P ≥ 0.43). MACE ambulators were more likely to be continent than MACE non-ambulators on multivariate analysis (OR 3.26, . P = 0.01). Discussion: This study reported higher than typical FI rates since: (1) it used a stringent definition of total fecal continence; (2) patients without FI were perhaps less likely to participate; and (3) it relied on patient-reported rather than clinician-reported outcomes. This cross-sectional study should not be interpreted as MACE procedure is ineffective; this would require a longitudinal study. The present findings may not apply to young children or those with significant developmental delay (patients excluded from the study). Conclusions: Ambulatory patients with SB are 50% more likely to have total fecal continence on long-term follow-up, particularly after a MACE procedure. Ambulatory status is a significant confounder of FI and should be considered in future analyses.Summary tablePredictors of fecal continence after MACE procedure.Summary tablePatient characteristicNo MACE (n = 57)MACE (n = 115)Non-ambulatory6/16 (37.5%)23/52 (44.2%)Ambulatory23/41 (56.1%)41/63 (65.1%) P-value0.250.04MACE, Malone antegrade continence enema. . .

AB - Introduction: While fecal incontinence (FI) affects many patients with spina bifida (SB), it is unclear if it is associated with ambulatory status. Objective: To determine if ambulatory status is associated with FI, and a potential confounding variable, in patients with and without a Malone antegrade continence enema (MACE). Study design: This study retrospectively reviewed of patients aged ≥8 years with SB who were enrolled in an international quality of life study at outpatient visits (January 2013 to September 2015). Patients reported FI over the last 4 weeks (strict criteria: any FI/accidents vs no FI). Patients unable to self-report FI due to developmental delay were excluded. Those who were ambulating outdoors with/without braces/crutches were considered community ambulators. Non-parametric tests and logistic regression were used for analysis. Results: A total of 115 patients with a MACE and 57 without a MACE were similar in gender (P = 0.99), ventriculoperitoneal status (P = 0.15) and age (16.0 vs 15.4 years, . P = 0.11). Median ages at MACE procedure and follow-up were 7.0 and 8.2 years, respectively, and all used the MACE ≥3x/week. They were less likely to be ambulators (54.8 vs 71.9%, . P = 0.03). In patients with a MACE, 64 (55.7%) had total fecal continence, compared with 29 (50.9%) without a MACE (P = 0.62). In the MACE group, ambulators were more likely to be continent compared with non-ambulatory patients (65.1 vs 44.2%, . P = 0.04) (Table). Although not statistically significant, a similar difference was observed in the non-MACE group (56.1 vs 37.5%, . P = 0.25). In the MACE group, continent and incontinent patients, regardless of ambulatory status, had similar rates of MACE use, additive use and time for MACE completion (P ≥ 0.43). MACE ambulators were more likely to be continent than MACE non-ambulators on multivariate analysis (OR 3.26, . P = 0.01). Discussion: This study reported higher than typical FI rates since: (1) it used a stringent definition of total fecal continence; (2) patients without FI were perhaps less likely to participate; and (3) it relied on patient-reported rather than clinician-reported outcomes. This cross-sectional study should not be interpreted as MACE procedure is ineffective; this would require a longitudinal study. The present findings may not apply to young children or those with significant developmental delay (patients excluded from the study). Conclusions: Ambulatory patients with SB are 50% more likely to have total fecal continence on long-term follow-up, particularly after a MACE procedure. Ambulatory status is a significant confounder of FI and should be considered in future analyses.Summary tablePredictors of fecal continence after MACE procedure.Summary tablePatient characteristicNo MACE (n = 57)MACE (n = 115)Non-ambulatory6/16 (37.5%)23/52 (44.2%)Ambulatory23/41 (56.1%)41/63 (65.1%) P-value0.250.04MACE, Malone antegrade continence enema. . .

KW - Ambulation

KW - Fecal incontinence

KW - Malone antegrade continence enema

KW - Spina bifida

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U2 - 10.1016/j.jpurol.2016.06.019

DO - 10.1016/j.jpurol.2016.06.019

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AN - SCOPUS:84995471862

JO - Journal of Pediatric Urology

JF - Journal of Pediatric Urology

SN - 1477-5131

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