Amiodarone reduces the prevalence of T wave alternans in a population with ventricular tachyarrhythmias

William Groh, Timothy S. Shinn, Erica E. Engelstein, Douglas P. Zipes

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Amiodarone and the Presence of TWA. Introduction: Testing for the presence of microvolt T wave alternans (TWA) is useful for arrhythmic risk stratification. Whether antiarrhythmic pharmacotherapy affects the presence of TWA is unknown. We tested whether patients with known ventricular tachyarrhythmias who were receiving amiodarone were less likely to manifest TWA as compared with those not receiving amiodarone. Methods and Results: Forty-four patients with a history of ventricular tachyarrhythmias and an implantable cardioverter defibrillator (ICD) implanted at least 1 month earlier underwent TWA testing. In this group, 14 patients were receiving amiodarone and 30 were not. Indeterminate test results occurred in 13 patients without a significant difference in those receiving or not receiving amiodarone. In the 31 patients with determinate TWA testing, a positive test was less likely in those receiving amiodarone (1 of 9 [11%]) as compared with those not receiving amiodarone (14 of 22 [64%]; P = 0.04). During a follow-up period averaging 0.9 ± 0.2 years, the presence of TWA (P = 0.04) and decreased left ventricular ejection fraction (P = 0.05) predicted appropriate ICD therapy for ventricular tachyarrhythmias. Conclusion: The prevalence of TWA was decreased in a chronic ventricular tachyarrhythmic population receiving amiodarone as compared with a population not receiving amiodarone.

Original languageEnglish
Pages (from-to)1335-1339
Number of pages5
JournalJournal of Cardiovascular Electrophysiology
Volume10
Issue number10
StatePublished - 1999

Fingerprint

Amiodarone
Tachycardia
Population
Implantable Defibrillators
Stroke Volume
Drug Therapy

Keywords

  • Amiodarone
  • T wave alternans
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Amiodarone reduces the prevalence of T wave alternans in a population with ventricular tachyarrhythmias. / Groh, William; Shinn, Timothy S.; Engelstein, Erica E.; Zipes, Douglas P.

In: Journal of Cardiovascular Electrophysiology, Vol. 10, No. 10, 1999, p. 1335-1339.

Research output: Contribution to journalArticle

Groh, William ; Shinn, Timothy S. ; Engelstein, Erica E. ; Zipes, Douglas P. / Amiodarone reduces the prevalence of T wave alternans in a population with ventricular tachyarrhythmias. In: Journal of Cardiovascular Electrophysiology. 1999 ; Vol. 10, No. 10. pp. 1335-1339.
@article{acf252dc68024e09a9a60b96c3f86a4b,
title = "Amiodarone reduces the prevalence of T wave alternans in a population with ventricular tachyarrhythmias",
abstract = "Amiodarone and the Presence of TWA. Introduction: Testing for the presence of microvolt T wave alternans (TWA) is useful for arrhythmic risk stratification. Whether antiarrhythmic pharmacotherapy affects the presence of TWA is unknown. We tested whether patients with known ventricular tachyarrhythmias who were receiving amiodarone were less likely to manifest TWA as compared with those not receiving amiodarone. Methods and Results: Forty-four patients with a history of ventricular tachyarrhythmias and an implantable cardioverter defibrillator (ICD) implanted at least 1 month earlier underwent TWA testing. In this group, 14 patients were receiving amiodarone and 30 were not. Indeterminate test results occurred in 13 patients without a significant difference in those receiving or not receiving amiodarone. In the 31 patients with determinate TWA testing, a positive test was less likely in those receiving amiodarone (1 of 9 [11{\%}]) as compared with those not receiving amiodarone (14 of 22 [64{\%}]; P = 0.04). During a follow-up period averaging 0.9 ± 0.2 years, the presence of TWA (P = 0.04) and decreased left ventricular ejection fraction (P = 0.05) predicted appropriate ICD therapy for ventricular tachyarrhythmias. Conclusion: The prevalence of TWA was decreased in a chronic ventricular tachyarrhythmic population receiving amiodarone as compared with a population not receiving amiodarone.",
keywords = "Amiodarone, T wave alternans, Ventricular tachycardia",
author = "William Groh and Shinn, {Timothy S.} and Engelstein, {Erica E.} and Zipes, {Douglas P.}",
year = "1999",
language = "English",
volume = "10",
pages = "1335--1339",
journal = "Journal of Cardiovascular Electrophysiology",
issn = "1045-3873",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Amiodarone reduces the prevalence of T wave alternans in a population with ventricular tachyarrhythmias

AU - Groh, William

AU - Shinn, Timothy S.

AU - Engelstein, Erica E.

AU - Zipes, Douglas P.

PY - 1999

Y1 - 1999

N2 - Amiodarone and the Presence of TWA. Introduction: Testing for the presence of microvolt T wave alternans (TWA) is useful for arrhythmic risk stratification. Whether antiarrhythmic pharmacotherapy affects the presence of TWA is unknown. We tested whether patients with known ventricular tachyarrhythmias who were receiving amiodarone were less likely to manifest TWA as compared with those not receiving amiodarone. Methods and Results: Forty-four patients with a history of ventricular tachyarrhythmias and an implantable cardioverter defibrillator (ICD) implanted at least 1 month earlier underwent TWA testing. In this group, 14 patients were receiving amiodarone and 30 were not. Indeterminate test results occurred in 13 patients without a significant difference in those receiving or not receiving amiodarone. In the 31 patients with determinate TWA testing, a positive test was less likely in those receiving amiodarone (1 of 9 [11%]) as compared with those not receiving amiodarone (14 of 22 [64%]; P = 0.04). During a follow-up period averaging 0.9 ± 0.2 years, the presence of TWA (P = 0.04) and decreased left ventricular ejection fraction (P = 0.05) predicted appropriate ICD therapy for ventricular tachyarrhythmias. Conclusion: The prevalence of TWA was decreased in a chronic ventricular tachyarrhythmic population receiving amiodarone as compared with a population not receiving amiodarone.

AB - Amiodarone and the Presence of TWA. Introduction: Testing for the presence of microvolt T wave alternans (TWA) is useful for arrhythmic risk stratification. Whether antiarrhythmic pharmacotherapy affects the presence of TWA is unknown. We tested whether patients with known ventricular tachyarrhythmias who were receiving amiodarone were less likely to manifest TWA as compared with those not receiving amiodarone. Methods and Results: Forty-four patients with a history of ventricular tachyarrhythmias and an implantable cardioverter defibrillator (ICD) implanted at least 1 month earlier underwent TWA testing. In this group, 14 patients were receiving amiodarone and 30 were not. Indeterminate test results occurred in 13 patients without a significant difference in those receiving or not receiving amiodarone. In the 31 patients with determinate TWA testing, a positive test was less likely in those receiving amiodarone (1 of 9 [11%]) as compared with those not receiving amiodarone (14 of 22 [64%]; P = 0.04). During a follow-up period averaging 0.9 ± 0.2 years, the presence of TWA (P = 0.04) and decreased left ventricular ejection fraction (P = 0.05) predicted appropriate ICD therapy for ventricular tachyarrhythmias. Conclusion: The prevalence of TWA was decreased in a chronic ventricular tachyarrhythmic population receiving amiodarone as compared with a population not receiving amiodarone.

KW - Amiodarone

KW - T wave alternans

KW - Ventricular tachycardia

UR - http://www.scopus.com/inward/record.url?scp=0032836369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032836369&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 1335

EP - 1339

JO - Journal of Cardiovascular Electrophysiology

JF - Journal of Cardiovascular Electrophysiology

SN - 1045-3873

IS - 10

ER -