Amphetamine enhances endurance by increasing heat dissipation

Ekaterina Morozova, Yeonjoo Yoo, Abolhassan Behrouzvaziri, Maria Zaretskaia, Daniel Rusyniak, Dmitry Zaretsky, Yaroslav Molkov

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Athletes use amphetamines to improve their performance through largely unknown mechanisms. Considering that body temperature is one of the major determinants of exhaustion during exercise, we investigated the influence of amphetamine on the thermoregulation. To explore this, we measured core body temperature and oxygen consumption of control and amphetamine-trea ted rats running on a treadmill with an incrementally increasing load (both speed and incline). Experimental results showed that rats treated with amphetamine (2 mg/kg) were able to run significantly longer than control rats. Due to a progressively increasing workload, which was matched by oxygen consumption, the control group exhibited a steady increase in the body temperature. The administration of amphetamine slowed down the temperature rise (thus decreasing core body temperature) in the beginning of the run without affecting oxygen consumption. In contrast, a lower dose of amphetamine (1 mg/kg) had no effect on measured parameters. Using a mathematical model describing temperature dynamics in two compartments (the core and the muscles), we were able to infer what physiological parameters were affected by amphetamine. Modeling revealed that amphetamine administration increases heat dissipation in the core. Furthermore, the model predicted that the muscle temperature at the end of the run in the amphetamine-treated group was significantly higher than in the control group. Therefore, we conclude that amphetamine may mask or delay fatigue by slowing down exercise-induced core body temperature growth by increasing heat dissipation. However, this affects the integrity of thermoregulatory system and may result in potentially dangerous overheating of the muscles.

Original languageEnglish (US)
Article numbere12955
JournalPhysiological Reports
Volume4
Issue number17
DOIs
StatePublished - Sep 1 2016

Fingerprint

Amphetamine
Hot Temperature
Body Temperature
Oxygen Consumption
Muscles
Temperature
Exercise
Amphetamines
Control Groups
Body Temperature Regulation
Masks
Workload
Running
Athletes
Fatigue
Theoretical Models
Growth

Keywords

  • Exercise
  • modeling
  • stimulants
  • thermoregulation

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology

Cite this

Morozova, E., Yoo, Y., Behrouzvaziri, A., Zaretskaia, M., Rusyniak, D., Zaretsky, D., & Molkov, Y. (2016). Amphetamine enhances endurance by increasing heat dissipation. Physiological Reports, 4(17), [e12955]. https://doi.org/10.14814/phy2.12955

Amphetamine enhances endurance by increasing heat dissipation. / Morozova, Ekaterina; Yoo, Yeonjoo; Behrouzvaziri, Abolhassan; Zaretskaia, Maria; Rusyniak, Daniel; Zaretsky, Dmitry; Molkov, Yaroslav.

In: Physiological Reports, Vol. 4, No. 17, e12955, 01.09.2016.

Research output: Contribution to journalArticle

Morozova, E, Yoo, Y, Behrouzvaziri, A, Zaretskaia, M, Rusyniak, D, Zaretsky, D & Molkov, Y 2016, 'Amphetamine enhances endurance by increasing heat dissipation', Physiological Reports, vol. 4, no. 17, e12955. https://doi.org/10.14814/phy2.12955
Morozova, Ekaterina ; Yoo, Yeonjoo ; Behrouzvaziri, Abolhassan ; Zaretskaia, Maria ; Rusyniak, Daniel ; Zaretsky, Dmitry ; Molkov, Yaroslav. / Amphetamine enhances endurance by increasing heat dissipation. In: Physiological Reports. 2016 ; Vol. 4, No. 17.
@article{1b7fc01058a74475ac9c3d51dd9fd3e6,
title = "Amphetamine enhances endurance by increasing heat dissipation",
abstract = "Athletes use amphetamines to improve their performance through largely unknown mechanisms. Considering that body temperature is one of the major determinants of exhaustion during exercise, we investigated the influence of amphetamine on the thermoregulation. To explore this, we measured core body temperature and oxygen consumption of control and amphetamine-trea ted rats running on a treadmill with an incrementally increasing load (both speed and incline). Experimental results showed that rats treated with amphetamine (2 mg/kg) were able to run significantly longer than control rats. Due to a progressively increasing workload, which was matched by oxygen consumption, the control group exhibited a steady increase in the body temperature. The administration of amphetamine slowed down the temperature rise (thus decreasing core body temperature) in the beginning of the run without affecting oxygen consumption. In contrast, a lower dose of amphetamine (1 mg/kg) had no effect on measured parameters. Using a mathematical model describing temperature dynamics in two compartments (the core and the muscles), we were able to infer what physiological parameters were affected by amphetamine. Modeling revealed that amphetamine administration increases heat dissipation in the core. Furthermore, the model predicted that the muscle temperature at the end of the run in the amphetamine-treated group was significantly higher than in the control group. Therefore, we conclude that amphetamine may mask or delay fatigue by slowing down exercise-induced core body temperature growth by increasing heat dissipation. However, this affects the integrity of thermoregulatory system and may result in potentially dangerous overheating of the muscles.",
keywords = "Exercise, modeling, stimulants, thermoregulation",
author = "Ekaterina Morozova and Yeonjoo Yoo and Abolhassan Behrouzvaziri and Maria Zaretskaia and Daniel Rusyniak and Dmitry Zaretsky and Yaroslav Molkov",
year = "2016",
month = "9",
day = "1",
doi = "10.14814/phy2.12955",
language = "English (US)",
volume = "4",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "John Wiley and Sons Inc.",
number = "17",

}

TY - JOUR

T1 - Amphetamine enhances endurance by increasing heat dissipation

AU - Morozova, Ekaterina

AU - Yoo, Yeonjoo

AU - Behrouzvaziri, Abolhassan

AU - Zaretskaia, Maria

AU - Rusyniak, Daniel

AU - Zaretsky, Dmitry

AU - Molkov, Yaroslav

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Athletes use amphetamines to improve their performance through largely unknown mechanisms. Considering that body temperature is one of the major determinants of exhaustion during exercise, we investigated the influence of amphetamine on the thermoregulation. To explore this, we measured core body temperature and oxygen consumption of control and amphetamine-trea ted rats running on a treadmill with an incrementally increasing load (both speed and incline). Experimental results showed that rats treated with amphetamine (2 mg/kg) were able to run significantly longer than control rats. Due to a progressively increasing workload, which was matched by oxygen consumption, the control group exhibited a steady increase in the body temperature. The administration of amphetamine slowed down the temperature rise (thus decreasing core body temperature) in the beginning of the run without affecting oxygen consumption. In contrast, a lower dose of amphetamine (1 mg/kg) had no effect on measured parameters. Using a mathematical model describing temperature dynamics in two compartments (the core and the muscles), we were able to infer what physiological parameters were affected by amphetamine. Modeling revealed that amphetamine administration increases heat dissipation in the core. Furthermore, the model predicted that the muscle temperature at the end of the run in the amphetamine-treated group was significantly higher than in the control group. Therefore, we conclude that amphetamine may mask or delay fatigue by slowing down exercise-induced core body temperature growth by increasing heat dissipation. However, this affects the integrity of thermoregulatory system and may result in potentially dangerous overheating of the muscles.

AB - Athletes use amphetamines to improve their performance through largely unknown mechanisms. Considering that body temperature is one of the major determinants of exhaustion during exercise, we investigated the influence of amphetamine on the thermoregulation. To explore this, we measured core body temperature and oxygen consumption of control and amphetamine-trea ted rats running on a treadmill with an incrementally increasing load (both speed and incline). Experimental results showed that rats treated with amphetamine (2 mg/kg) were able to run significantly longer than control rats. Due to a progressively increasing workload, which was matched by oxygen consumption, the control group exhibited a steady increase in the body temperature. The administration of amphetamine slowed down the temperature rise (thus decreasing core body temperature) in the beginning of the run without affecting oxygen consumption. In contrast, a lower dose of amphetamine (1 mg/kg) had no effect on measured parameters. Using a mathematical model describing temperature dynamics in two compartments (the core and the muscles), we were able to infer what physiological parameters were affected by amphetamine. Modeling revealed that amphetamine administration increases heat dissipation in the core. Furthermore, the model predicted that the muscle temperature at the end of the run in the amphetamine-treated group was significantly higher than in the control group. Therefore, we conclude that amphetamine may mask or delay fatigue by slowing down exercise-induced core body temperature growth by increasing heat dissipation. However, this affects the integrity of thermoregulatory system and may result in potentially dangerous overheating of the muscles.

KW - Exercise

KW - modeling

KW - stimulants

KW - thermoregulation

UR - http://www.scopus.com/inward/record.url?scp=84987851417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84987851417&partnerID=8YFLogxK

U2 - 10.14814/phy2.12955

DO - 10.14814/phy2.12955

M3 - Article

C2 - 27604402

AN - SCOPUS:84987851417

VL - 4

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 17

M1 - e12955

ER -