Amphetamine inhibits behavior-related neuronal responses in substantia nigra pars reticulata of rats working for sucrose reinforcement

Joshua M. Gulley, Ann Kosobud, George V. Rebec

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Changes in activity of basal ganglia neurons, especially those in the striatum, are thought to underlie the characteristic behavioral patterns produced by d-amphetamine (AMPH). To study the role of the substantia nigra pars reticulata (SNr), a major basal ganglia output nucleus, we recorded from SNr neurons before and after a behaviorally activating dose of AMPH (0.5 mg/kg) in rats trained to nosepoke for sucrose reinforcement. Before AMPH, task-related behaviors were associated primarily with increases or both increases and decreases in SNr firing. Although these same behavior-related patterns persisted after AMPH, their relative magnitude was significantly attenuated. Units unresponsive during task events were unaffected by AMPH. Thus, rather than change the overall level of SNr firing, a behaviorally active dose of AMPH exerts context-dependent effects on the activity of SNr neurons.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalNeuroscience Letters
Volume322
Issue number3
StatePublished - Apr 12 2002

Fingerprint

Amphetamine
Sucrose
Basal Ganglia
Neurons
Dextroamphetamine
Pars Reticulata
Reinforcement (Psychology)

Keywords

  • Amphetamine
  • Behaving rats
  • Movement-related neurons
  • Nosepoke
  • Operant behavior
  • Single-unit activity
  • Substantia nigra pars reticulata

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Amphetamine inhibits behavior-related neuronal responses in substantia nigra pars reticulata of rats working for sucrose reinforcement. / Gulley, Joshua M.; Kosobud, Ann; Rebec, George V.

In: Neuroscience Letters, Vol. 322, No. 3, 12.04.2002, p. 165-168.

Research output: Contribution to journalArticle

@article{2273fc7b5cf94f5db33af1cf538750a5,
title = "Amphetamine inhibits behavior-related neuronal responses in substantia nigra pars reticulata of rats working for sucrose reinforcement",
abstract = "Changes in activity of basal ganglia neurons, especially those in the striatum, are thought to underlie the characteristic behavioral patterns produced by d-amphetamine (AMPH). To study the role of the substantia nigra pars reticulata (SNr), a major basal ganglia output nucleus, we recorded from SNr neurons before and after a behaviorally activating dose of AMPH (0.5 mg/kg) in rats trained to nosepoke for sucrose reinforcement. Before AMPH, task-related behaviors were associated primarily with increases or both increases and decreases in SNr firing. Although these same behavior-related patterns persisted after AMPH, their relative magnitude was significantly attenuated. Units unresponsive during task events were unaffected by AMPH. Thus, rather than change the overall level of SNr firing, a behaviorally active dose of AMPH exerts context-dependent effects on the activity of SNr neurons.",
keywords = "Amphetamine, Behaving rats, Movement-related neurons, Nosepoke, Operant behavior, Single-unit activity, Substantia nigra pars reticulata",
author = "Gulley, {Joshua M.} and Ann Kosobud and Rebec, {George V.}",
year = "2002",
month = "4",
day = "12",
language = "English",
volume = "322",
pages = "165--168",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Amphetamine inhibits behavior-related neuronal responses in substantia nigra pars reticulata of rats working for sucrose reinforcement

AU - Gulley, Joshua M.

AU - Kosobud, Ann

AU - Rebec, George V.

PY - 2002/4/12

Y1 - 2002/4/12

N2 - Changes in activity of basal ganglia neurons, especially those in the striatum, are thought to underlie the characteristic behavioral patterns produced by d-amphetamine (AMPH). To study the role of the substantia nigra pars reticulata (SNr), a major basal ganglia output nucleus, we recorded from SNr neurons before and after a behaviorally activating dose of AMPH (0.5 mg/kg) in rats trained to nosepoke for sucrose reinforcement. Before AMPH, task-related behaviors were associated primarily with increases or both increases and decreases in SNr firing. Although these same behavior-related patterns persisted after AMPH, their relative magnitude was significantly attenuated. Units unresponsive during task events were unaffected by AMPH. Thus, rather than change the overall level of SNr firing, a behaviorally active dose of AMPH exerts context-dependent effects on the activity of SNr neurons.

AB - Changes in activity of basal ganglia neurons, especially those in the striatum, are thought to underlie the characteristic behavioral patterns produced by d-amphetamine (AMPH). To study the role of the substantia nigra pars reticulata (SNr), a major basal ganglia output nucleus, we recorded from SNr neurons before and after a behaviorally activating dose of AMPH (0.5 mg/kg) in rats trained to nosepoke for sucrose reinforcement. Before AMPH, task-related behaviors were associated primarily with increases or both increases and decreases in SNr firing. Although these same behavior-related patterns persisted after AMPH, their relative magnitude was significantly attenuated. Units unresponsive during task events were unaffected by AMPH. Thus, rather than change the overall level of SNr firing, a behaviorally active dose of AMPH exerts context-dependent effects on the activity of SNr neurons.

KW - Amphetamine

KW - Behaving rats

KW - Movement-related neurons

KW - Nosepoke

KW - Operant behavior

KW - Single-unit activity

KW - Substantia nigra pars reticulata

UR - http://www.scopus.com/inward/record.url?scp=0037066385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037066385&partnerID=8YFLogxK

M3 - Article

VL - 322

SP - 165

EP - 168

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -