Amphetamine neurotoxicity

Cause and consequence of oxidative stress

Bryan Yamamoto, Michael G. Bankson

Research output: Contribution to journalReview article

99 Citations (Scopus)

Abstract

Oxidative stress has been demonstrated to occur in response to high doses of substituted amphetamines such as methamphetamine (METH) and 3,4-methlyene-dioxymethamphetamine (MDMA). This term represents a set of complex and multi-faceted precursor events that occur in both a parallel and serial manner, eventually converging to produce oxidative damage. This critical review goes beyond the compilation of previously well-documented evidence demonstrating that oxidative stress mediates METH and MDMA toxicity to dopamine and/or serotonin nerve terminals. The diverse causes, effects, and impact of pro-oxidative processes produced by these drugs are highlighted, integrated, and assembled into a proposed temporal sequence in an effort to explain the long-term neurochemical changes produced by amphetamines. Multiple factors are considered, including dopamine, glutamate, impaired mitochondrial bioenergetics, and inflammatory processes, all of which converge and are necessary but alone may be insufficient to cause damage to dopamine and/or 5-HT terminals. In addition, the processes linking inflammation and oxidative stress are considered and described as a feedforward process. The self-perpetuating cycle of inflammation and oxidative stress that is initiated by dopamine, glutamate, and mitochondrial dysfunction may extend well beyond the acute pharmacodynamic effects of the drugs and could represent an underlying and potentially progressive degenerative process.

Original languageEnglish (US)
Pages (from-to)87-117
Number of pages31
JournalCritical Reviews in Neurobiology
Volume17
Issue number2
StatePublished - 2005
Externally publishedYes

Fingerprint

Amphetamine
Dopamine
Oxidative Stress
Amphetamines
Methamphetamine
Glutamic Acid
Serotonin
Inflammation
Pharmaceutical Preparations
Energy Metabolism

Keywords

  • Bioenergetics
  • Dopamine
  • Glutamate
  • Inflammation
  • MDMA
  • Methamphetamine
  • Mitochondria
  • Neurotoxicity
  • Oxidative stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology
  • Neuroscience(all)

Cite this

Amphetamine neurotoxicity : Cause and consequence of oxidative stress. / Yamamoto, Bryan; Bankson, Michael G.

In: Critical Reviews in Neurobiology, Vol. 17, No. 2, 2005, p. 87-117.

Research output: Contribution to journalReview article

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