Amphotropic murine leukemia retrovirus is not an acute pathogen for primates

Kenneth Cornetta, Robert C. Moen, Kenneth Culver, Richard A. Morgan, Jeanne R. McLachlin, Sabine Sturm, Jane Selegue, William London, R. Michael Blaese, W. French Anderson

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

The in vivo fate of amphotropic murine leukemia retrovirus was studied in five rhesus monkeys. Retrovirus infused intravenously into 3 normal animals and 1 immunosuppressed animal was cleared rapidly from the circulation and subsequent viremia has not been detected (mean follow-up of 27.4 months). A fifth monkey was immunosuppressed and transplanted with virus-producing autologous fibroblasts in addition to an intraperitoneal injection of virus. This animal was viremic for 2 days and its lymph node cells and peripheral blood mononuclear cells were shown to be producing virus for up to 22 days post-inoculation, but subsequently has been negative after 17.0 months of analysis. In the 5 animals studied (combined mean follow-up of 25.7 months), clinical illness has not been identified at any time. Therefore, murine amphotropic retroviruses do not appear to pose an acute health risk.

Original languageEnglish (US)
Pages (from-to)15-30
Number of pages16
JournalHuman Gene Therapy
Volume1
Issue number1
StatePublished - 1990
Externally publishedYes

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Retroviridae
Primates
Leukemia
Viruses
Viremia
Intraperitoneal Injections
Macaca mulatta
Haplorhini
Blood Cells
Fibroblasts
Lymph Nodes
Health

ASJC Scopus subject areas

  • Genetics

Cite this

Cornetta, K., Moen, R. C., Culver, K., Morgan, R. A., McLachlin, J. R., Sturm, S., ... Anderson, W. F. (1990). Amphotropic murine leukemia retrovirus is not an acute pathogen for primates. Human Gene Therapy, 1(1), 15-30.

Amphotropic murine leukemia retrovirus is not an acute pathogen for primates. / Cornetta, Kenneth; Moen, Robert C.; Culver, Kenneth; Morgan, Richard A.; McLachlin, Jeanne R.; Sturm, Sabine; Selegue, Jane; London, William; Blaese, R. Michael; Anderson, W. French.

In: Human Gene Therapy, Vol. 1, No. 1, 1990, p. 15-30.

Research output: Contribution to journalArticle

Cornetta, K, Moen, RC, Culver, K, Morgan, RA, McLachlin, JR, Sturm, S, Selegue, J, London, W, Blaese, RM & Anderson, WF 1990, 'Amphotropic murine leukemia retrovirus is not an acute pathogen for primates', Human Gene Therapy, vol. 1, no. 1, pp. 15-30.
Cornetta K, Moen RC, Culver K, Morgan RA, McLachlin JR, Sturm S et al. Amphotropic murine leukemia retrovirus is not an acute pathogen for primates. Human Gene Therapy. 1990;1(1):15-30.
Cornetta, Kenneth ; Moen, Robert C. ; Culver, Kenneth ; Morgan, Richard A. ; McLachlin, Jeanne R. ; Sturm, Sabine ; Selegue, Jane ; London, William ; Blaese, R. Michael ; Anderson, W. French. / Amphotropic murine leukemia retrovirus is not an acute pathogen for primates. In: Human Gene Therapy. 1990 ; Vol. 1, No. 1. pp. 15-30.
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