Amplified in breast cancer 1 expression in breast cancer

M. A. Thorat, D. Turbin, A. Morimiya, S. Leung, Q. Zhang, M. H. Jeng, D. G. Huntsman, H. Nakshatri, S. Badve

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Aims: The amplified in breast cancer 1 (AIB1), steroid receptor co-activator family member, acts as an oestrogen receptor (ER) co-activator. Acting with HER-2, it is thought to play a role in endocrine resistance by facilitating ER-growth factor crosstalk. The aim was to analyse AIB1 expression by immunohistochemistry and study its correlations with other prognostic variables in breast cancer and its effect on survival. Methods: A tissue microarray comprising tumours from 438 patients with 15.4 years' median follow-up was used. Interpretable AIB1 expression obtained in 395 patients was analysed along with other prognostic factors in breast cancer. Results: AIB1 expression scores ranged from 0 to 30; positive AIB1 expression (score > 14) was seen in 146/395 breast cancers; it correlated negatively with ER (P = 0.003) and progesterone receptor (PR) (P = 0.007), and positively with HER-2 (P = 0.005) and tumour grade (P = 0.014). It did not correlate with nodal status (P = 0.437). Among ER+ patients, AIB1 expression showed a trend towards loss of PR expression (29% versus 20%; P = 0.14). AIB1 did not predict survival on univariate or multivariate analysis. Conclusions: AIB1 expression correlates with HER-2 expression in breast cancer and shows a trend of association with loss of PR expression in ER+ tumours. Our study supports the postulated role of AIB1 in ER-growth factor interactions.

Original languageEnglish (US)
Pages (from-to)634-641
Number of pages8
JournalHistopathology
Volume53
Issue number6
DOIs
StatePublished - Dec 1 2008

Keywords

  • Amplified in breast cancer 1
  • Breast cancer
  • Human epidermal growth factor receptor 2
  • Oestrogen receptor
  • Prognosis
  • Steroid receptor co-activator 3

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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  • Cite this

    Thorat, M. A., Turbin, D., Morimiya, A., Leung, S., Zhang, Q., Jeng, M. H., Huntsman, D. G., Nakshatri, H., & Badve, S. (2008). Amplified in breast cancer 1 expression in breast cancer. Histopathology, 53(6), 634-641. https://doi.org/10.1111/j.1365-2559.2008.03155.x