Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: Preliminary results from the COGA project

B. Porjesz, H. Begleiter, T. Reich, P. Van Eerdewegh, Howard Edenberg, Tatiana Foroud, A. Goate, A. Litke, D. B. Chorlian, A. Stimus, J. Rice, J. Blangero, L. Almasy, J. Sorbell, L. O. Bauer, S. Kuperman, Sean O'Connor, J. Rohrbaugh

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Recent data collected at six identical electrophysiological laboratories from the large national multisite Collaborative Study on the Genetics of Alcoholism provide evidence for considering the P3 amplitude of the event- related potential as a phenotypic marker for the risk of alcoholism. The distribution of P3 amplitude to target stimuli at the Pz electrode in individuals 16 years of age and over from 163 randomly ascertained control families (n = 687) was compared with those from 219 densely affected alcoholic families (n = 1276) in which three directly interviewed first- degree relatives met both DSM-III-R and Feighner criteria at the definite level for alcohol dependence (stage II). The control sample did not exclude individuals with psychiatric illness or alcoholism to obtain incidence rates of psychiatric disorders similar to those of the general population. P3 amplitude data from control families was converted to Z-scores, and a P3 amplitude beyond 2 SD's below the mean was considered an 'abnormal trait.' When age- and sex-matched distributions of P3 amplitude were compared, members of densely affected stage II families were more likely to manifest low P3 amplitudes (2 SD below the mean) than members of control families, comparing affected and unaffected offspring, and all individuals; all comparisons of these distributions between groups were significant (p < 0.00001). P3 amplitude means were also significantly lower in stage II family members, compared with control family members for all comparisons, namely probands, affected and unaffected individuals (p < 0.0001), and offspring (p < 0.01). Furthermore, affected individuals from stage II families, but not control families, had significantly lower P3 amplitudes than unaffected individuals (p < 0.001). Affected males from stage II families had significantly lower P3 amplitudes than affected females (p < 0.001). Recent linkage analyses indicate that visual P3 amplitude provides a biological phenotypic marker that has genetic underpinnings.

Original languageEnglish
Pages (from-to)1317-1323
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume22
Issue number6
StatePublished - Sep 1998

Fingerprint

P300 Event-Related Potentials
Alcoholism
Psychiatry
Alcohols
Sex Distribution
Electrodes
Alcoholics
Diagnostic and Statistical Manual of Mental Disorders
Biomarkers

Keywords

  • Alcoholism
  • ERPs
  • Genetics
  • Phenotypic Markers

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism : Preliminary results from the COGA project. / Porjesz, B.; Begleiter, H.; Reich, T.; Van Eerdewegh, P.; Edenberg, Howard; Foroud, Tatiana; Goate, A.; Litke, A.; Chorlian, D. B.; Stimus, A.; Rice, J.; Blangero, J.; Almasy, L.; Sorbell, J.; Bauer, L. O.; Kuperman, S.; O'Connor, Sean; Rohrbaugh, J.

In: Alcoholism: Clinical and Experimental Research, Vol. 22, No. 6, 09.1998, p. 1317-1323.

Research output: Contribution to journalArticle

Porjesz, B, Begleiter, H, Reich, T, Van Eerdewegh, P, Edenberg, H, Foroud, T, Goate, A, Litke, A, Chorlian, DB, Stimus, A, Rice, J, Blangero, J, Almasy, L, Sorbell, J, Bauer, LO, Kuperman, S, O'Connor, S & Rohrbaugh, J 1998, 'Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: Preliminary results from the COGA project', Alcoholism: Clinical and Experimental Research, vol. 22, no. 6, pp. 1317-1323.
Porjesz, B. ; Begleiter, H. ; Reich, T. ; Van Eerdewegh, P. ; Edenberg, Howard ; Foroud, Tatiana ; Goate, A. ; Litke, A. ; Chorlian, D. B. ; Stimus, A. ; Rice, J. ; Blangero, J. ; Almasy, L. ; Sorbell, J. ; Bauer, L. O. ; Kuperman, S. ; O'Connor, Sean ; Rohrbaugh, J. / Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism : Preliminary results from the COGA project. In: Alcoholism: Clinical and Experimental Research. 1998 ; Vol. 22, No. 6. pp. 1317-1323.
@article{3cb945b7b9144401b7819083e1071598,
title = "Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism: Preliminary results from the COGA project",
abstract = "Recent data collected at six identical electrophysiological laboratories from the large national multisite Collaborative Study on the Genetics of Alcoholism provide evidence for considering the P3 amplitude of the event- related potential as a phenotypic marker for the risk of alcoholism. The distribution of P3 amplitude to target stimuli at the Pz electrode in individuals 16 years of age and over from 163 randomly ascertained control families (n = 687) was compared with those from 219 densely affected alcoholic families (n = 1276) in which three directly interviewed first- degree relatives met both DSM-III-R and Feighner criteria at the definite level for alcohol dependence (stage II). The control sample did not exclude individuals with psychiatric illness or alcoholism to obtain incidence rates of psychiatric disorders similar to those of the general population. P3 amplitude data from control families was converted to Z-scores, and a P3 amplitude beyond 2 SD's below the mean was considered an 'abnormal trait.' When age- and sex-matched distributions of P3 amplitude were compared, members of densely affected stage II families were more likely to manifest low P3 amplitudes (2 SD below the mean) than members of control families, comparing affected and unaffected offspring, and all individuals; all comparisons of these distributions between groups were significant (p < 0.00001). P3 amplitude means were also significantly lower in stage II family members, compared with control family members for all comparisons, namely probands, affected and unaffected individuals (p < 0.0001), and offspring (p < 0.01). Furthermore, affected individuals from stage II families, but not control families, had significantly lower P3 amplitudes than unaffected individuals (p < 0.001). Affected males from stage II families had significantly lower P3 amplitudes than affected females (p < 0.001). Recent linkage analyses indicate that visual P3 amplitude provides a biological phenotypic marker that has genetic underpinnings.",
keywords = "Alcoholism, ERPs, Genetics, Phenotypic Markers",
author = "B. Porjesz and H. Begleiter and T. Reich and {Van Eerdewegh}, P. and Howard Edenberg and Tatiana Foroud and A. Goate and A. Litke and Chorlian, {D. B.} and A. Stimus and J. Rice and J. Blangero and L. Almasy and J. Sorbell and Bauer, {L. O.} and S. Kuperman and Sean O'Connor and J. Rohrbaugh",
year = "1998",
month = "9",
language = "English",
volume = "22",
pages = "1317--1323",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Amplitude of visual P3 event-related potential as a phenotypic marker for a predisposition to alcoholism

T2 - Preliminary results from the COGA project

AU - Porjesz, B.

AU - Begleiter, H.

AU - Reich, T.

AU - Van Eerdewegh, P.

AU - Edenberg, Howard

AU - Foroud, Tatiana

AU - Goate, A.

AU - Litke, A.

AU - Chorlian, D. B.

AU - Stimus, A.

AU - Rice, J.

AU - Blangero, J.

AU - Almasy, L.

AU - Sorbell, J.

AU - Bauer, L. O.

AU - Kuperman, S.

AU - O'Connor, Sean

AU - Rohrbaugh, J.

PY - 1998/9

Y1 - 1998/9

N2 - Recent data collected at six identical electrophysiological laboratories from the large national multisite Collaborative Study on the Genetics of Alcoholism provide evidence for considering the P3 amplitude of the event- related potential as a phenotypic marker for the risk of alcoholism. The distribution of P3 amplitude to target stimuli at the Pz electrode in individuals 16 years of age and over from 163 randomly ascertained control families (n = 687) was compared with those from 219 densely affected alcoholic families (n = 1276) in which three directly interviewed first- degree relatives met both DSM-III-R and Feighner criteria at the definite level for alcohol dependence (stage II). The control sample did not exclude individuals with psychiatric illness or alcoholism to obtain incidence rates of psychiatric disorders similar to those of the general population. P3 amplitude data from control families was converted to Z-scores, and a P3 amplitude beyond 2 SD's below the mean was considered an 'abnormal trait.' When age- and sex-matched distributions of P3 amplitude were compared, members of densely affected stage II families were more likely to manifest low P3 amplitudes (2 SD below the mean) than members of control families, comparing affected and unaffected offspring, and all individuals; all comparisons of these distributions between groups were significant (p < 0.00001). P3 amplitude means were also significantly lower in stage II family members, compared with control family members for all comparisons, namely probands, affected and unaffected individuals (p < 0.0001), and offspring (p < 0.01). Furthermore, affected individuals from stage II families, but not control families, had significantly lower P3 amplitudes than unaffected individuals (p < 0.001). Affected males from stage II families had significantly lower P3 amplitudes than affected females (p < 0.001). Recent linkage analyses indicate that visual P3 amplitude provides a biological phenotypic marker that has genetic underpinnings.

AB - Recent data collected at six identical electrophysiological laboratories from the large national multisite Collaborative Study on the Genetics of Alcoholism provide evidence for considering the P3 amplitude of the event- related potential as a phenotypic marker for the risk of alcoholism. The distribution of P3 amplitude to target stimuli at the Pz electrode in individuals 16 years of age and over from 163 randomly ascertained control families (n = 687) was compared with those from 219 densely affected alcoholic families (n = 1276) in which three directly interviewed first- degree relatives met both DSM-III-R and Feighner criteria at the definite level for alcohol dependence (stage II). The control sample did not exclude individuals with psychiatric illness or alcoholism to obtain incidence rates of psychiatric disorders similar to those of the general population. P3 amplitude data from control families was converted to Z-scores, and a P3 amplitude beyond 2 SD's below the mean was considered an 'abnormal trait.' When age- and sex-matched distributions of P3 amplitude were compared, members of densely affected stage II families were more likely to manifest low P3 amplitudes (2 SD below the mean) than members of control families, comparing affected and unaffected offspring, and all individuals; all comparisons of these distributions between groups were significant (p < 0.00001). P3 amplitude means were also significantly lower in stage II family members, compared with control family members for all comparisons, namely probands, affected and unaffected individuals (p < 0.0001), and offspring (p < 0.01). Furthermore, affected individuals from stage II families, but not control families, had significantly lower P3 amplitudes than unaffected individuals (p < 0.001). Affected males from stage II families had significantly lower P3 amplitudes than affected females (p < 0.001). Recent linkage analyses indicate that visual P3 amplitude provides a biological phenotypic marker that has genetic underpinnings.

KW - Alcoholism

KW - ERPs

KW - Genetics

KW - Phenotypic Markers

UR - http://www.scopus.com/inward/record.url?scp=0031659386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031659386&partnerID=8YFLogxK

M3 - Article

C2 - 9756048

AN - SCOPUS:0031659386

VL - 22

SP - 1317

EP - 1323

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 6

ER -