Amyloid fibril protein nomenclature

2010 recommendations from the nomenclature committee of the International Society of Amyloidosis

Jean D. Sipe, Merrill Benson, Joel N. Buxbaum, Shu Ichi Ikeda, Giampaolo Merlini, Maria J M Saraiva, Per Westermark

Research output: Contribution to journalArticle

230 Citations (Scopus)

Abstract

A system of amyloid fibril nomenclature based on the chemical identity of the amyloid fibril forming protein is recommended. This system has been in use for approximately 40 years, but current literature remains confused with clinical and histochemical designations used when the amyloid disease processes were poorly understood. To be designated an amyloid fibril protein, the protein must occur in tissue deposits and exhibit affinity for Congo red and green birefringence when viewed by polarisation microscopy. Furthermore, the protein must have been unambiguously characterised by protein sequence analysis (DNA sequencing in the case of familial diseases). Current nomenclature lists of 27 human and nine animal fibril proteins are provided together with a list of eight inclusion bodies that exhibit some of the properties of amyloid fibrils.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalAmyloid
Volume17
Issue number3-4
DOIs
StatePublished - Sep 2010

Fingerprint

Amyloidogenic Proteins
Amyloidosis
Amyloid
Terminology
Proteins
Polarization Microscopy
Birefringence
Congo Red
Inclusion Bodies
Protein Sequence Analysis
DNA Sequence Analysis

Keywords

  • amyloid fibril
  • amyloid protein
  • Amyloidosis
  • inclusion body

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Amyloid fibril protein nomenclature : 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis. / Sipe, Jean D.; Benson, Merrill; Buxbaum, Joel N.; Ikeda, Shu Ichi; Merlini, Giampaolo; Saraiva, Maria J M; Westermark, Per.

In: Amyloid, Vol. 17, No. 3-4, 09.2010, p. 101-104.

Research output: Contribution to journalArticle

Sipe, Jean D. ; Benson, Merrill ; Buxbaum, Joel N. ; Ikeda, Shu Ichi ; Merlini, Giampaolo ; Saraiva, Maria J M ; Westermark, Per. / Amyloid fibril protein nomenclature : 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis. In: Amyloid. 2010 ; Vol. 17, No. 3-4. pp. 101-104.
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