Abstract
Posttraumatic stress disorder (PTSD) often precedes comorbid substance use disorder and has been associated with aggression. Prior research has evidenced that alcohol use and other externalizing behaviors share genetic factors with PTSD; however, few studies have examined if specific genes are associated with externalizing behaviors in PTSD. The purpose of the current study was to investigate whether an α-synuclein gene polymorphism (SNCA rs356195) moderates the association of PTSD symptomatology with externalizing behaviors. We examined the separate and combined effects of PTSD symptomatology and SNCA rs356195 on alcohol- and aggression-related measures in nonclinical participants (N = 138 European Americans; 15 diagnosed with probable PTSD). Probable PTSD status and SNCA were both associated with externalizing measures. SNCA also moderated the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures. Current findings suggest that variations in SNCA may increase the likelihood that PTSD symptomatology results in excessive alcohol use.
| Original language | English |
|---|---|
| Pages (from-to) | 41-47 |
| Number of pages | 7 |
| Journal | Journal of Anxiety Disorders |
| Volume | 30 |
| DOIs | |
| State | Published - Mar 1 2015 |
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Keywords
- Aggression
- Alcohol use
- Impulsivity
- Posttraumatic stress disorder
- α-Synuclein
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
An α-synuclein gene (SNCA) polymorphism moderates the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures. / Guillot, Casey R.; Fanning, Jennifer R.; Liang, Tiebing; Leventhal, Adam M.; Berman, Mitchell E.
In: Journal of Anxiety Disorders, Vol. 30, 01.03.2015, p. 41-47.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An α-synuclein gene (SNCA) polymorphism moderates the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures
AU - Guillot, Casey R.
AU - Fanning, Jennifer R.
AU - Liang, Tiebing
AU - Leventhal, Adam M.
AU - Berman, Mitchell E.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Posttraumatic stress disorder (PTSD) often precedes comorbid substance use disorder and has been associated with aggression. Prior research has evidenced that alcohol use and other externalizing behaviors share genetic factors with PTSD; however, few studies have examined if specific genes are associated with externalizing behaviors in PTSD. The purpose of the current study was to investigate whether an α-synuclein gene polymorphism (SNCA rs356195) moderates the association of PTSD symptomatology with externalizing behaviors. We examined the separate and combined effects of PTSD symptomatology and SNCA rs356195 on alcohol- and aggression-related measures in nonclinical participants (N = 138 European Americans; 15 diagnosed with probable PTSD). Probable PTSD status and SNCA were both associated with externalizing measures. SNCA also moderated the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures. Current findings suggest that variations in SNCA may increase the likelihood that PTSD symptomatology results in excessive alcohol use.
AB - Posttraumatic stress disorder (PTSD) often precedes comorbid substance use disorder and has been associated with aggression. Prior research has evidenced that alcohol use and other externalizing behaviors share genetic factors with PTSD; however, few studies have examined if specific genes are associated with externalizing behaviors in PTSD. The purpose of the current study was to investigate whether an α-synuclein gene polymorphism (SNCA rs356195) moderates the association of PTSD symptomatology with externalizing behaviors. We examined the separate and combined effects of PTSD symptomatology and SNCA rs356195 on alcohol- and aggression-related measures in nonclinical participants (N = 138 European Americans; 15 diagnosed with probable PTSD). Probable PTSD status and SNCA were both associated with externalizing measures. SNCA also moderated the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures. Current findings suggest that variations in SNCA may increase the likelihood that PTSD symptomatology results in excessive alcohol use.
KW - Aggression
KW - Alcohol use
KW - Impulsivity
KW - Posttraumatic stress disorder
KW - α-Synuclein
UR - http://www.scopus.com/inward/record.url?scp=84921362837&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84921362837&partnerID=8YFLogxK
U2 - 10.1016/j.janxdis.2014.12.007
DO - 10.1016/j.janxdis.2014.12.007
M3 - Article
C2 - 25594371
AN - SCOPUS:84921362837
VL - 30
SP - 41
EP - 47
JO - Journal of Anxiety Disorders
JF - Journal of Anxiety Disorders
SN - 0887-6185
ER -