An α-synuclein gene (SNCA) polymorphism moderates the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures

Casey R. Guillot; Jennifer R. Fanning; Tiebing Liang; Adam M. Leventhal; Mitchell E. Berman

doi:10.1016/j.janxdis.2014.12.007

An α-synuclein gene (SNCA) polymorphism moderates the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures

Casey R. Guillot, Jennifer R. Fanning, Tiebing Liang, Adam M. Leventhal, Mitchell E. Berman

Endocrinology & Metabolism

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Posttraumatic stress disorder (PTSD) often precedes comorbid substance use disorder and has been associated with aggression. Prior research has evidenced that alcohol use and other externalizing behaviors share genetic factors with PTSD; however, few studies have examined if specific genes are associated with externalizing behaviors in PTSD. The purpose of the current study was to investigate whether an α-synuclein gene polymorphism (SNCA rs356195) moderates the association of PTSD symptomatology with externalizing behaviors. We examined the separate and combined effects of PTSD symptomatology and SNCA rs356195 on alcohol- and aggression-related measures in nonclinical participants (N = 138 European Americans; 15 diagnosed with probable PTSD). Probable PTSD status and SNCA were both associated with externalizing measures. SNCA also moderated the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures. Current findings suggest that variations in SNCA may increase the likelihood that PTSD symptomatology results in excessive alcohol use.

Original language	English (US)
Pages (from-to)	41-47
Number of pages	7
Journal	Journal of Anxiety Disorders
Volume	30
DOIs	https://doi.org/10.1016/j.janxdis.2014.12.007
State	Published - Mar 1 2015

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Keywords

Aggression
Alcohol use
Impulsivity
Posttraumatic stress disorder
α-Synuclein

ASJC Scopus subject areas

Psychiatry and Mental health
Clinical Psychology

Cite this

Guillot, C. R., Fanning, J. R., Liang, T., Leventhal, A. M., & Berman, M. E. (2015). An α-synuclein gene (SNCA) polymorphism moderates the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures. Journal of Anxiety Disorders, 30, 41-47. https://doi.org/10.1016/j.janxdis.2014.12.007

An α-synuclein gene (SNCA) polymorphism moderates the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures. / Guillot, Casey R.; Fanning, Jennifer R.; Liang, Tiebing; Leventhal, Adam M.; Berman, Mitchell E.

In: Journal of Anxiety Disorders, Vol. 30, 01.03.2015, p. 41-47.

Research output: Contribution to journal › Article

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10.1016/j.janxdis.2014.12.007