An 18O2-target for the high yield production of 18F-fluoride

R. J. Nickles, R. D. Hichwa, M. E. Daube, Gary Hutchins, D. D. Congdon

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A high-pressure target for the production of 18F-fluoride via 18O(p,n)18F is described. A small-volume chamber receives a standard 10 mL, glass test tube with a silvered interior. The 18O2 target gas is admitted, irradiated, then retrieved without losses into a reservoir by cryogenic pumping. At 10-MeV proton energy, 150 mCi/μA end-of-saturated-bombardment (EOSB) activities of 18F are conveniently deposited on the inner surface of the target liner. This liner is removed and serves as the reaction flask for various syntheses needing precursor 18F-fluoride. Production of the simple fluoralkane CH3 18F has been chosen as the standard reaction, due to its clinical demand in the assessment of regional cerebral blood flow.

Original languageEnglish (US)
Pages (from-to)625-629
Number of pages5
JournalThe International Journal Of Applied Radiation And Isotopes
Volume34
Issue number3
DOIs
StatePublished - 1983
Externally publishedYes

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Fluorides
fluorides
Cerebrovascular Circulation
linings
Regional Blood Flow
Cryogenics
Glass
flasks
Protons
Blood
Gases
blood flow
proton energy
Pressure
cryogenics
bombardment
pumping
chambers
tubes
glass

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

An 18O2-target for the high yield production of 18F-fluoride. / Nickles, R. J.; Hichwa, R. D.; Daube, M. E.; Hutchins, Gary; Congdon, D. D.

In: The International Journal Of Applied Radiation And Isotopes, Vol. 34, No. 3, 1983, p. 625-629.

Research output: Contribution to journalArticle

Nickles, R. J. ; Hichwa, R. D. ; Daube, M. E. ; Hutchins, Gary ; Congdon, D. D. / An 18O2-target for the high yield production of 18F-fluoride. In: The International Journal Of Applied Radiation And Isotopes. 1983 ; Vol. 34, No. 3. pp. 625-629.
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