An alphabet of amino acid conformations in protein

R. T. Miller, R. J. Douthart, A. K. Dunker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

An approach to the representation of individual amino acids using dihedral angle measurements, based on the maxi-min distance algorithm presented by J.T. Tou and R.C. Gonzalez (1974), is outlined. The methodology, based on maxi-min and data set partitions, generates 124 distinct cluster centers from 19121 total residues. While only 18 of the 124 capture 1% or more of the data set, the first cis-proline conformation is 49th in population and suggests that over fifty centers may be significant. Four applications of these centers are demonstrated: representation of individual proteins, tripeptide sequence dependency, analysis of neighboring centers, and a simple structure prediction algorithm.

Original languageEnglish (US)
Title of host publicationProceedings of the 26th Hawaii International Conference on System Sciences, HICSS 1993
PublisherIEEE Computer Society
Pages689-698
Number of pages10
ISBN (Electronic)0818632305
DOIs
StatePublished - Jan 1 1993
Externally publishedYes
Event26th Hawaii International Conference on System Sciences, HICSS 1993 - Wailea, United States
Duration: Jan 8 1993 → …

Publication series

NameProceedings of the Annual Hawaii International Conference on System Sciences
Volume1
ISSN (Print)1530-1605

Conference

Conference26th Hawaii International Conference on System Sciences, HICSS 1993
CountryUnited States
CityWailea
Period1/8/93 → …

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Miller, R. T., Douthart, R. J., & Dunker, A. K. (1993). An alphabet of amino acid conformations in protein. In Proceedings of the 26th Hawaii International Conference on System Sciences, HICSS 1993 (pp. 689-698). [270672] (Proceedings of the Annual Hawaii International Conference on System Sciences; Vol. 1). IEEE Computer Society. https://doi.org/10.1109/HICSS.1993.270672