An alphabet of amino acid conformations in protein

R. T. Miller, R. J. Douthart, A. Dunker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

An approach to the representation of individual amino acids using dihedral angle measurements, based on the maxi-min distance algorithm presented by J.T. Tou and R.C. Gonzalez (1974), is outlined. The methodology, based on maxi-min and data set partitions, generates 124 distinct cluster centers from 19121 total residues. While only 18 of the 124 capture 1% or more of the data set, the first cis-proline conformation is 49th in population and suggests that over fifty centers may be significant. Four applications of these centers are demonstrated: representation of individual proteins, tripeptide sequence dependency, analysis of neighboring centers, and a simple structure prediction algorithm.

Original languageEnglish (US)
Title of host publicationProceedings of the 26th Hawaii International Conference on System Sciences, HICSS 1993
PublisherIEEE Computer Society
Pages689-698
Number of pages10
ISBN (Electronic)0818632305
DOIs
StatePublished - Jan 1 1993
Externally publishedYes
Event26th Hawaii International Conference on System Sciences, HICSS 1993 - Wailea, United States
Duration: Jan 8 1993 → …

Publication series

NameProceedings of the Annual Hawaii International Conference on System Sciences
Volume1
ISSN (Print)1530-1605

Conference

Conference26th Hawaii International Conference on System Sciences, HICSS 1993
CountryUnited States
CityWailea
Period1/8/93 → …

Fingerprint

Conformations
Amino acids
Proteins
Dihedral angle
Angle measurement

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Miller, R. T., Douthart, R. J., & Dunker, A. (1993). An alphabet of amino acid conformations in protein. In Proceedings of the 26th Hawaii International Conference on System Sciences, HICSS 1993 (pp. 689-698). [270672] (Proceedings of the Annual Hawaii International Conference on System Sciences; Vol. 1). IEEE Computer Society. https://doi.org/10.1109/HICSS.1993.270672

An alphabet of amino acid conformations in protein. / Miller, R. T.; Douthart, R. J.; Dunker, A.

Proceedings of the 26th Hawaii International Conference on System Sciences, HICSS 1993. IEEE Computer Society, 1993. p. 689-698 270672 (Proceedings of the Annual Hawaii International Conference on System Sciences; Vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Miller, RT, Douthart, RJ & Dunker, A 1993, An alphabet of amino acid conformations in protein. in Proceedings of the 26th Hawaii International Conference on System Sciences, HICSS 1993., 270672, Proceedings of the Annual Hawaii International Conference on System Sciences, vol. 1, IEEE Computer Society, pp. 689-698, 26th Hawaii International Conference on System Sciences, HICSS 1993, Wailea, United States, 1/8/93. https://doi.org/10.1109/HICSS.1993.270672
Miller RT, Douthart RJ, Dunker A. An alphabet of amino acid conformations in protein. In Proceedings of the 26th Hawaii International Conference on System Sciences, HICSS 1993. IEEE Computer Society. 1993. p. 689-698. 270672. (Proceedings of the Annual Hawaii International Conference on System Sciences). https://doi.org/10.1109/HICSS.1993.270672
Miller, R. T. ; Douthart, R. J. ; Dunker, A. / An alphabet of amino acid conformations in protein. Proceedings of the 26th Hawaii International Conference on System Sciences, HICSS 1993. IEEE Computer Society, 1993. pp. 689-698 (Proceedings of the Annual Hawaii International Conference on System Sciences).
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