An effective method for measuring salivary lithium in patients on anticholinergic drugs

D. Selinger, S. Simmons, A. W. Hailer, John Nurnberger, E. S. Gershon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The parotid salivary response to citric acid and cholinergic agonist and antagonist was assessed in normal volunteers. Gustatory stimulation by circulation of citric acid in the mouth evoked reproducible parotid salivary burst. The salivary response to citric acid was minimally affected by anticholinergic drugs. Analysis of citric acid-evoked parotid saliva revealed a linear relationship between saliva and serum lithium concentrations in affectively ill patients treated with lithium only, or with lithium in combination with anticholinergic drugs. We suggest that parotid saliva lithium levels can be used to guide lithium therapy in patients for whom phlebotomy is not practical.

Original languageEnglish (US)
Pages (from-to)1145-1155
Number of pages11
JournalBiological Psychiatry
Volume17
Issue number10
StatePublished - 1982
Externally publishedYes

Fingerprint

Cholinergic Antagonists
Lithium
Citric Acid
Saliva
Pharmaceutical Preparations
Cholinergic Agonists
Phlebotomy
Mouth
Healthy Volunteers
Serum

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Selinger, D., Simmons, S., Hailer, A. W., Nurnberger, J., & Gershon, E. S. (1982). An effective method for measuring salivary lithium in patients on anticholinergic drugs. Biological Psychiatry, 17(10), 1145-1155.

An effective method for measuring salivary lithium in patients on anticholinergic drugs. / Selinger, D.; Simmons, S.; Hailer, A. W.; Nurnberger, John; Gershon, E. S.

In: Biological Psychiatry, Vol. 17, No. 10, 1982, p. 1145-1155.

Research output: Contribution to journalArticle

Selinger, D, Simmons, S, Hailer, AW, Nurnberger, J & Gershon, ES 1982, 'An effective method for measuring salivary lithium in patients on anticholinergic drugs', Biological Psychiatry, vol. 17, no. 10, pp. 1145-1155.
Selinger, D. ; Simmons, S. ; Hailer, A. W. ; Nurnberger, John ; Gershon, E. S. / An effective method for measuring salivary lithium in patients on anticholinergic drugs. In: Biological Psychiatry. 1982 ; Vol. 17, No. 10. pp. 1145-1155.
@article{9f8febd7e1664a3e9c843952b691877e,
title = "An effective method for measuring salivary lithium in patients on anticholinergic drugs",
abstract = "The parotid salivary response to citric acid and cholinergic agonist and antagonist was assessed in normal volunteers. Gustatory stimulation by circulation of citric acid in the mouth evoked reproducible parotid salivary burst. The salivary response to citric acid was minimally affected by anticholinergic drugs. Analysis of citric acid-evoked parotid saliva revealed a linear relationship between saliva and serum lithium concentrations in affectively ill patients treated with lithium only, or with lithium in combination with anticholinergic drugs. We suggest that parotid saliva lithium levels can be used to guide lithium therapy in patients for whom phlebotomy is not practical.",
author = "D. Selinger and S. Simmons and Hailer, {A. W.} and John Nurnberger and Gershon, {E. S.}",
year = "1982",
language = "English (US)",
volume = "17",
pages = "1145--1155",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "10",

}

TY - JOUR

T1 - An effective method for measuring salivary lithium in patients on anticholinergic drugs

AU - Selinger, D.

AU - Simmons, S.

AU - Hailer, A. W.

AU - Nurnberger, John

AU - Gershon, E. S.

PY - 1982

Y1 - 1982

N2 - The parotid salivary response to citric acid and cholinergic agonist and antagonist was assessed in normal volunteers. Gustatory stimulation by circulation of citric acid in the mouth evoked reproducible parotid salivary burst. The salivary response to citric acid was minimally affected by anticholinergic drugs. Analysis of citric acid-evoked parotid saliva revealed a linear relationship between saliva and serum lithium concentrations in affectively ill patients treated with lithium only, or with lithium in combination with anticholinergic drugs. We suggest that parotid saliva lithium levels can be used to guide lithium therapy in patients for whom phlebotomy is not practical.

AB - The parotid salivary response to citric acid and cholinergic agonist and antagonist was assessed in normal volunteers. Gustatory stimulation by circulation of citric acid in the mouth evoked reproducible parotid salivary burst. The salivary response to citric acid was minimally affected by anticholinergic drugs. Analysis of citric acid-evoked parotid saliva revealed a linear relationship between saliva and serum lithium concentrations in affectively ill patients treated with lithium only, or with lithium in combination with anticholinergic drugs. We suggest that parotid saliva lithium levels can be used to guide lithium therapy in patients for whom phlebotomy is not practical.

UR - http://www.scopus.com/inward/record.url?scp=0020363909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020363909&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 1145

EP - 1155

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 10

ER -