An interactive 3D visualization and manipulation tool for effective assessment of angiogenesis and arteriogenesis using computed tomographic angiography

Li Shen, Ling Gao, Zhenwu Zhuang, Ebo DeMuinck, Heng Huang, Fillia Makedon, Justin Pearlman

Research output: Contribution to journalConference article

1 Scopus citations


This paper presents IVM, an Interactive Vessel Manipulation tool that can help make effective and efficient assessment of angiogenesis and arteriogenesis in computed tomographic angiography (CTA) studies. IVM consists of three fundamental components: (1) a visualization component, (2) a tracing component, and (3) a measurement component. Given a user-specified threshold, IVM can create a 3D surface visualization based on it. Since vessels are thin and tubular structures, using standard isosurface extraction techniques usually cannot yield satisfactory reconstructions. Instead, IVM directly renders the surface of a derived binary 3D image. The image volumes collected in CTA studies often have a relatively high resolution. Thus, compared with more complicated vessel extraction and visualization techniques, rendering the binary image surface has the advantages of being effective, simple and fast. IVM employs a semi-automatic approach to determine the threshold: a user can adjust the threshold by checking the corresponding 3D surface reconstruction and make the choice. Typical tracing software often defines ROIs on 3D image volumes using three orthogonal views. The tracing component in IVM takes one step further: it can perform tracing not only on image slices but also in a 3D view. We observe that directly operating on a 3D view can help a tracer identify ROIs more easily. After setting a threshold and tracing an ROI, a user can use IVM's measurement component to estimate the volume and other parameters of vessels in the ROI. The effectiveness of the IVM tool is demonstrated on rat vessel/bone images collected in a previous CTA study.

Original languageEnglish (US)
Article number98
Pages (from-to)848-858
Number of pages11
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Issue numberII
StatePublished - Aug 16 2005
Externally publishedYes
EventMedical Imaging 2005 - Visualization, Image-Guided Procedures, and Display - San Diego, CA, United States
Duration: Feb 13 2005Feb 15 2005


  • 3D surface visualization
  • Computed tomographic angiography
  • Region of interest
  • Vessel extraction

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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