An investigation of the visual disturbances experienced by patients on clomiphene citrate

Lyne Racette, Peter R. Casson, Paul Claman, David H. Zackon, Evanne J. Casson

Research output: Contribution to journalArticle

16 Scopus citations


Objective: To evaluate the impact of clomiphene citrate on vision. Design: Observational study. Setting: Patients were referred to the University of Ottawa Eye Institute ophthalmology clinic from the Department of Obstetrics and Gynaecology of the Ottawa Hospital-General Campus. Patient(s): Eight adult females taking clomiphene citrate and experiencing visual disturbances. Intervention(s): Patients received a comprehensive visual evaluation twice: once during a washout period, and once during an active clomiphene citrate treatment. Main Outcome Measure(s): Ophthalmologic examination, color vision, visual acuity, contrast sensitivity, visual fields using standard automated perimetry, and foveal flicker sensitivity at high (32 Hz) and low (8 Hz) temporal frequencies. Result(s): We found no differences between the washout and clomiphene citrate conditions for color vision, visual acuity, contrast sensitivity, and visual fields. The only statistically significant difference was found for foveal flicker sensitivity at 32 Hz in the right eye, with a similar trend in the left eye and at 8 Hz in both eyes. Conclusion(s): The effect of clomiphene citrate on vision was minimal, and the visual disturbances were reversible in all patients. A bilateral reduction in flicker sensitivity was the only observed visual disturbance. Women who experience visual symptoms associated with clomiphene citrate should be monitored, but therapy can usually be maintained.

Original languageEnglish (US)
Pages (from-to)1169-1172
Number of pages4
JournalFertility and Sterility
Issue number4
StatePublished - Mar 1 2010


  • Clomid
  • Clomiphene citrate
  • Serophene
  • visual dysfunction
  • visual side effects

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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