An ocular view of the IGF-IGFBP system

Dung V. Nguyen, Sergio Li Calzi, Lynn C. Shaw, Jennifer L. Kielczewski, Hannah E. Korah, Maria B. Grant

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

IGFs and their binding proteins have been shown to exhibit both protective and deleterious effects in ocular disease. Recent studies have characterized the expression patterns of different IGFBPs in retinal layers and within the vitreous. IGFBP-3 has roles in vascular protection stimulating proliferation, migration, and differentiation of vascular progenitor cells to sites of injury. IGFBP-3 increases pericyte ensheathment and shows anti-inflammatory effects by reducing microglia activation in diabetes. IGFBP-5 has recently been linked to mediating fibrosis in proliferative vitreoretinopathy but also reduces neovascularization. Thus, the regulatory balance between IGF and IGFBPs can have profound impact on target tissues. This review discusses recent findings of IGF and IGFBP expression in the eye with relevance to different retinopathies.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalGrowth Hormone and IGF Research
Volume23
Issue number3
DOIs
StatePublished - Jun 1 2013

Keywords

  • Blood retinal barrier
  • Hypoxia
  • IGF
  • IGF binding protein
  • Retinopathy
  • Vascular protection

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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  • Cite this

    Nguyen, D. V., Li Calzi, S., Shaw, L. C., Kielczewski, J. L., Korah, H. E., & Grant, M. B. (2013). An ocular view of the IGF-IGFBP system. Growth Hormone and IGF Research, 23(3), 45-52. https://doi.org/10.1016/j.ghir.2013.03.001