An ultrasonically powered implantable Micro-Oxygen generator (IMOG)

Teimour Maleki, Ning Cao, Seung Hyun Song, Chinghai Kao, Song Chu Arthur Ko, Babak Ziaie

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

In this paper, we present an ultrasonically powered implantable micro-oxygen generator (IMOG) that is capable of in situ tumor oxygenation through water electrolysis. Such active mode of oxygen generation is not affected by increased interstitial pressure or abnormal blood vessels that typically limit the systemic delivery of oxygen to hypoxic regions of solid tumors. Wireless ultrasonic powering (2.15MHz) was employed to increase the penetration depth and eliminate the directional sensitivity associated with magnetic methods. In addition, ultrasonic powering allowed for further reduction in the total size of the implant by eliminating the need for a large area inductor. IMOG has an overall dimension of 1.2 mm × 1.3 mm × 8mm, small enough to be implanted using a hypodermic needle or a trocar. In vitro and ex vivo experiments showed that IMOG is capable of generating more than 150μA which, in turn, can create 0.525μL/min of oxygen through electrolytic disassociation. In vivo experiments in a well-known hypoxic pancreatic tumor models (1 cm 3 in size) also verified adequate in situ tumor oxygenation in less than 10 min.

Original languageEnglish
Article number5975204
Pages (from-to)3104-3111
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume58
Issue number11
DOIs
StatePublished - Nov 2011

Fingerprint

Oxygen
Tumors
Oxygenation
Ultrasonics
Blood vessels
Electrolysis
Needles
Experiments
Water

Keywords

  • Hypoxia
  • radiation treatment
  • tumor oxygenation
  • ultrasonic powering
  • water electrolysis

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

An ultrasonically powered implantable Micro-Oxygen generator (IMOG). / Maleki, Teimour; Cao, Ning; Song, Seung Hyun; Kao, Chinghai; Arthur Ko, Song Chu; Ziaie, Babak.

In: IEEE Transactions on Biomedical Engineering, Vol. 58, No. 11, 5975204, 11.2011, p. 3104-3111.

Research output: Contribution to journalArticle

Maleki, T, Cao, N, Song, SH, Kao, C, Arthur Ko, SC & Ziaie, B 2011, 'An ultrasonically powered implantable Micro-Oxygen generator (IMOG)', IEEE Transactions on Biomedical Engineering, vol. 58, no. 11, 5975204, pp. 3104-3111. https://doi.org/10.1109/TBME.2011.2163634
Maleki, Teimour ; Cao, Ning ; Song, Seung Hyun ; Kao, Chinghai ; Arthur Ko, Song Chu ; Ziaie, Babak. / An ultrasonically powered implantable Micro-Oxygen generator (IMOG). In: IEEE Transactions on Biomedical Engineering. 2011 ; Vol. 58, No. 11. pp. 3104-3111.
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