An unexpected version of horror autotoxicus: Anaphylactic shock to a self-peptide

Rosetta Pedotti, Dennis Mitchell, Jochen Wedemeyer, Marcela Karpuj, Dorothée Chabas, Eyas M. Hattab, Mindy Tsai, Stephen J. Galli, Lawrence Steinman

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (TH1) cell-mediated autoimmune disease, it can also be induced by TH2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is associated with exposure to a foreign antigen that is often derived from medication, insect venom or food. We report here that, after self-tolerance to myelin is destroyed, anaphylaxis may be triggered by a self-antigen, in this case a myelin peptide. "Horror autotoxicus", which was initially described by Ehrlich, may not only include autoimmunity to self, it may also encompass immediate hypersensitivity to self, which leads to shock and rapid death.

Original languageEnglish (US)
Pages (from-to)216-222
Number of pages7
JournalNature Immunology
Volume2
Issue number3
DOIs
StatePublished - Mar 2001
Externally publishedYes

Fingerprint

Autoimmune Experimental Encephalomyelitis
Anaphylaxis
Myelin Sheath
Self Tolerance
Immediate Hypersensitivity
Peptides
Th1 Cells
Venoms
Autoantigens
Autoimmunity
Autoimmune Diseases
Insects
Shock
Hypersensitivity
Antigens
Food

ASJC Scopus subject areas

  • Immunology

Cite this

Pedotti, R., Mitchell, D., Wedemeyer, J., Karpuj, M., Chabas, D., Hattab, E. M., ... Steinman, L. (2001). An unexpected version of horror autotoxicus: Anaphylactic shock to a self-peptide. Nature Immunology, 2(3), 216-222. https://doi.org/10.1038/85266

An unexpected version of horror autotoxicus : Anaphylactic shock to a self-peptide. / Pedotti, Rosetta; Mitchell, Dennis; Wedemeyer, Jochen; Karpuj, Marcela; Chabas, Dorothée; Hattab, Eyas M.; Tsai, Mindy; Galli, Stephen J.; Steinman, Lawrence.

In: Nature Immunology, Vol. 2, No. 3, 03.2001, p. 216-222.

Research output: Contribution to journalArticle

Pedotti, R, Mitchell, D, Wedemeyer, J, Karpuj, M, Chabas, D, Hattab, EM, Tsai, M, Galli, SJ & Steinman, L 2001, 'An unexpected version of horror autotoxicus: Anaphylactic shock to a self-peptide', Nature Immunology, vol. 2, no. 3, pp. 216-222. https://doi.org/10.1038/85266
Pedotti R, Mitchell D, Wedemeyer J, Karpuj M, Chabas D, Hattab EM et al. An unexpected version of horror autotoxicus: Anaphylactic shock to a self-peptide. Nature Immunology. 2001 Mar;2(3):216-222. https://doi.org/10.1038/85266
Pedotti, Rosetta ; Mitchell, Dennis ; Wedemeyer, Jochen ; Karpuj, Marcela ; Chabas, Dorothée ; Hattab, Eyas M. ; Tsai, Mindy ; Galli, Stephen J. ; Steinman, Lawrence. / An unexpected version of horror autotoxicus : Anaphylactic shock to a self-peptide. In: Nature Immunology. 2001 ; Vol. 2, No. 3. pp. 216-222.
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