An unusual ostensible example of intraoral basal cell carcinoma

Ioannis G. Koutlas, Christian A. Koch, Robert A. Vickers, Frederieke M. Brouwers, Alexander Vortmeyer

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

An example of oral basal cell carcinoma is presented originating on the posterior mandibular mucosa and gingiva of a 67-year-old female. Histologically, it featured a multifocal pattern. It recurred eight times in a period of 20 years. Tissue samples of the tumor were evaluated with monoclonal antibody Ber-EP4 and were compared with examples of oral mucosa, skin, oral and cutaneous squamous cell carcinoma, peripheral ameloblastoma, ameloblastoma and cutaneous basal cell carcinoma (BCC). Only neoplastic basal cells showed positive immunohistochemical staining. Additionally, microdissected neoplastic areas were evaluated for loss of heterozygosity (LOH) of the PTCH gene with markers D9S303, D9S252 and D9S287. PTCH gene mutations are reported in patients with Gorlin syndrome and sporadic cutaneous BCCs. Loss of one allele was observed with all three markers. Examples of conventional ameloblastomas did not show evidence of LOH. These observations support the inclusion of BCC in the differential diagnosis of appropriate oral mucosal neoplasms. Koutlas IG, Koch CA, Vickers RA, Brouwers FM, Vortmeyer AO. An unusual ostensible example of intraoral basal cell carcinoma.

Original languageEnglish (US)
Pages (from-to)464-470
Number of pages7
JournalJournal of Cutaneous Pathology
Volume36
Issue number4
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

Fingerprint

Basal Cell Carcinoma
Ameloblastoma
Skin
Loss of Heterozygosity
Basal Cell Nevus Syndrome
Mouth Neoplasms
Mouth Mucosa
Gingiva
Genes
Squamous Cell Carcinoma
Mucous Membrane
Differential Diagnosis
Alleles
Staining and Labeling
Mutation
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

An unusual ostensible example of intraoral basal cell carcinoma. / Koutlas, Ioannis G.; Koch, Christian A.; Vickers, Robert A.; Brouwers, Frederieke M.; Vortmeyer, Alexander.

In: Journal of Cutaneous Pathology, Vol. 36, No. 4, 01.04.2009, p. 464-470.

Research output: Contribution to journalArticle

Koutlas, Ioannis G. ; Koch, Christian A. ; Vickers, Robert A. ; Brouwers, Frederieke M. ; Vortmeyer, Alexander. / An unusual ostensible example of intraoral basal cell carcinoma. In: Journal of Cutaneous Pathology. 2009 ; Vol. 36, No. 4. pp. 464-470.
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