An update on the treatment of precocious puberty in McCune-Albright syndrome and testotoxicosis

Nadine Haddad, Erica Eugster

Research output: Contribution to journalReview article

17 Scopus citations


McCune-Albright syndrome and testotoxicosis are rare forms of peripheral precocious puberty. Our understanding of the pathophysiology and mechanism of these diseases has significantly increased following identification of their underlying molecular etiology. However, their treatment remains challenging. We provide a review of the various treatment modalities used in both conditions with an update on recent trials using novel and promising pharmacological agents.

Original languageEnglish (US)
Pages (from-to)653-661
Number of pages9
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number6
StatePublished - Jun 2007



  • Aromatase inhibitors
  • McCune-Albright syndrome
  • Testotoxicosis

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

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