Analysis of exome sequences with and without incorporating prior biological knowledge

Junghyun Namkung, Paola Raska, Jia Kang, Yunlong Liu, Qing Lu, Xiaofeng Zhu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Next-generation sequencing technology provides new opportunities and challenges in the search for genetic variants that underlie complex traits. It will also presumably uncover many new rare variants, but exactly how these variants should be incorporated into the data analysis remains a question. Several papers in our group from Genetic Analysis Workshop 17 evaluated different methods of rare variant analysis, including single-variant, gene-based, and pathway-based analyses and analyses that incorporated biological information. Although the performance of some of these methods strongly depends on the underlying disease model, integration of known biological information is helpful in detecting causal genes. Two work groups demonstrated that use of a Bayesian network and a collapsing receiver operating characteristic curve approach improves risk prediction when a disease is caused by many rare variants. Another work group suggested that modeling local rather than global ancestry may be beneficial when controlling the effect of population structure in rare variant association analysis.

Original languageEnglish (US)
Pages (from-to)S48-S55
JournalGenetic epidemiology
Issue numberSUPPL. 1
StatePublished - 2011


  • Association analysis
  • Bayesian network
  • Biological information
  • Population structure
  • Rare variant
  • Receiver operating characteristic
  • Risk prediction model

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

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