Analysis of expression of the microphthalmia gene in vitiligo (miut /miut) mutant mice

N. Bora, Simon Conway

Research output: Contribution to journalArticle

Abstract

Purpose: Viriligo (miut/miut) mice have i slow progressive loss of photoreceptor cells and abnormalities within the RPE including uneven pigmentation, reduced outer segment disk phagocytosis and abnormal microvillous processes. The genetic defect in this mutant is a point mutation in the microphthalmia (mi) gene, which codes for a basichelix-loop-helix zipper protein, a putative regulator of the transcription of some pigmentation genes. The purpose of this study was to assess the onset and spatial pattern of expression of m mRNA in vitiligo mutants. Methods: Mutant and wildrype embryos at various stages of d

Original languageEnglish (US)
JournalInvestigative Ophthalmology and Visual Science
Volume38
Issue number4
StatePublished - 1997
Externally publishedYes

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Microphthalmos
Vitiligo
Pigmentation
Gene Expression
Photoreceptor Cells
Phagocytosis
Point Mutation
Genes
Embryonic Structures
Messenger RNA
Proteins

ASJC Scopus subject areas

  • Ophthalmology

Cite this

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