Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

Ken Randall, Jason Stevens, Juan Yepes, Marcus E. Randall, Mahesh Kudrimoti, Jonathan Feddock, Jing Xi, Richard J. Kryscio, Craig S. Miller

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed. Methods: A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week 2 and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined. Results: HNC subjects experienced mean SSFR decline of 36% by visit 2 (N = 27; P = .012) and 57% by visit 3 (N = 20; P = .0004). Concentrations of calcium and MUC5b increased, but not significantly during IMRT (P > .05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (P < .04) and linear mixed models (P < .0001). Conclusions: Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia.

Original languageEnglish (US)
Pages (from-to)772-779
Number of pages8
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume115
Issue number6
DOIs
StatePublished - Jun 1 2013
Externally publishedYes

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Xerostomia
Intensity-Modulated Radiotherapy
Statistical Factor Analysis
Mucin-5B
Radiotherapy
Saliva
Head and Neck Neoplasms
Calcium
Parotid Gland
Linear Models
Radiation
Equipment and Supplies

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Dentistry (miscellaneous)

Cite this

Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy. / Randall, Ken; Stevens, Jason; Yepes, Juan; Randall, Marcus E.; Kudrimoti, Mahesh; Feddock, Jonathan; Xi, Jing; Kryscio, Richard J.; Miller, Craig S.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 115, No. 6, 01.06.2013, p. 772-779.

Research output: Contribution to journalArticle

Randall, Ken ; Stevens, Jason ; Yepes, Juan ; Randall, Marcus E. ; Kudrimoti, Mahesh ; Feddock, Jonathan ; Xi, Jing ; Kryscio, Richard J. ; Miller, Craig S. / Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy. In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2013 ; Vol. 115, No. 6. pp. 772-779.
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