Analysis of longitudinal censored semicontinuous data with application to the study of executive dysfunction: The Towers Task

Spencer Lourens, Ying Zhang, Jeffrey D. Long, Jane S. Paulsen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Executive dysfunction is a deficiency in skills of planning and problem solving that characterizes many neuropsychiatric disorders. The Towers Task is a commonly used measure of planning and problem solving for assessing executive function. Towers Task data are usually zero-inflated and right-censored, and ignoring these features can result in biased inference for the disease characterization of executive dysfunction. In this manuscript, a mixed-effects model for longitudinal censored semicontinuous data is developed for analyzing longitudinal Towers Task data from the PREDICT-HD study. The model is contrasted with current practice, and implications for general use are discussed.

Original languageEnglish (US)
Pages (from-to)865-879
Number of pages15
JournalStatistical Methods in Medical Research
Volume26
Issue number2
DOIs
StatePublished - Apr 1 2017

Fingerprint

Executive Function
Planning
General Practice
Mixed Effects Model
Biased
Disorder
Zero
Model
Skills

Keywords

  • censored data
  • Cognitive neuroscience
  • Huntington disease
  • mixed-effect model
  • semicontinuous data
  • Towers Task

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability
  • Health Information Management

Cite this

Analysis of longitudinal censored semicontinuous data with application to the study of executive dysfunction : The Towers Task. / Lourens, Spencer; Zhang, Ying; Long, Jeffrey D.; Paulsen, Jane S.

In: Statistical Methods in Medical Research, Vol. 26, No. 2, 01.04.2017, p. 865-879.

Research output: Contribution to journalArticle

@article{31113dfa166a454f9e539301b32e94dc,
title = "Analysis of longitudinal censored semicontinuous data with application to the study of executive dysfunction: The Towers Task",
abstract = "Executive dysfunction is a deficiency in skills of planning and problem solving that characterizes many neuropsychiatric disorders. The Towers Task is a commonly used measure of planning and problem solving for assessing executive function. Towers Task data are usually zero-inflated and right-censored, and ignoring these features can result in biased inference for the disease characterization of executive dysfunction. In this manuscript, a mixed-effects model for longitudinal censored semicontinuous data is developed for analyzing longitudinal Towers Task data from the PREDICT-HD study. The model is contrasted with current practice, and implications for general use are discussed.",
keywords = "censored data, Cognitive neuroscience, Huntington disease, mixed-effect model, semicontinuous data, Towers Task",
author = "Spencer Lourens and Ying Zhang and Long, {Jeffrey D.} and Paulsen, {Jane S.}",
year = "2017",
month = "4",
day = "1",
doi = "10.1177/0962280214560187",
language = "English (US)",
volume = "26",
pages = "865--879",
journal = "Statistical Methods in Medical Research",
issn = "0962-2802",
publisher = "SAGE Publications Ltd",
number = "2",

}

TY - JOUR

T1 - Analysis of longitudinal censored semicontinuous data with application to the study of executive dysfunction

T2 - The Towers Task

AU - Lourens, Spencer

AU - Zhang, Ying

AU - Long, Jeffrey D.

AU - Paulsen, Jane S.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Executive dysfunction is a deficiency in skills of planning and problem solving that characterizes many neuropsychiatric disorders. The Towers Task is a commonly used measure of planning and problem solving for assessing executive function. Towers Task data are usually zero-inflated and right-censored, and ignoring these features can result in biased inference for the disease characterization of executive dysfunction. In this manuscript, a mixed-effects model for longitudinal censored semicontinuous data is developed for analyzing longitudinal Towers Task data from the PREDICT-HD study. The model is contrasted with current practice, and implications for general use are discussed.

AB - Executive dysfunction is a deficiency in skills of planning and problem solving that characterizes many neuropsychiatric disorders. The Towers Task is a commonly used measure of planning and problem solving for assessing executive function. Towers Task data are usually zero-inflated and right-censored, and ignoring these features can result in biased inference for the disease characterization of executive dysfunction. In this manuscript, a mixed-effects model for longitudinal censored semicontinuous data is developed for analyzing longitudinal Towers Task data from the PREDICT-HD study. The model is contrasted with current practice, and implications for general use are discussed.

KW - censored data

KW - Cognitive neuroscience

KW - Huntington disease

KW - mixed-effect model

KW - semicontinuous data

KW - Towers Task

UR - http://www.scopus.com/inward/record.url?scp=85018770072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018770072&partnerID=8YFLogxK

U2 - 10.1177/0962280214560187

DO - 10.1177/0962280214560187

M3 - Article

C2 - 25431462

AN - SCOPUS:85018770072

VL - 26

SP - 865

EP - 879

JO - Statistical Methods in Medical Research

JF - Statistical Methods in Medical Research

SN - 0962-2802

IS - 2

ER -