Analysis of serum and urinal copper and zinc in chinese northeast population with the prediabetes or diabetes with and without complications

Jiancheng Xu, Qi Zhou, Gilbert Liu, Yi Tan, Lu Cai

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

This study investigated the association of copper and zinc levels in the serum or urine of patients living in northeast China, with either prediabetes or diabetes. From January 2010 to October 2011, patients with type 1 diabetes (T1D, n = 25), type 2 diabetes (T2D, n = 137), impaired fasting glucose (IFG, n = 12) or impaired glucose tolerance (IGT, n = 15), and age/gender matched controls (n = 50) were enrolled. In the T2D group, there were 24 patients with nephropathy, 34 with retinopathy, and 50 with peripheral neuropathy. Serum copper levels were significantly higher in IFG, IGT, and T2D groups. Serum zinc level was dramatically lower, and urinary zinc level was significantly higher in both T1D and T2D subjects compared with controls. The serum zinc/copper ratio was significantly lower in all the patients with IFG, ITG, T1D, and T2D. The serum copper level was positively associated with HbA1c in T2D subjects. Simvastatin treatment in T2D patients had no significant effect on serum and urinary copper and zinc. These results suggest the need for further studies of the potential impact of the imbalanced serum copper and zinc levels on metabolic syndrome, diabetes, and diabetic complications.

Original languageEnglish (US)
Article number635214
JournalOxidative Medicine and Cellular Longevity
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Prediabetic State
Medical problems
Zinc
Copper
Serum
Population
Insulated gate bipolar transistors (IGBT)
Diabetes Complications
Glucose
Simvastatin
Glucose Intolerance
Peripheral Nervous System Diseases
Bathroom Equipment
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Fasting
China
Urine

ASJC Scopus subject areas

  • Cell Biology
  • Aging
  • Biochemistry
  • Medicine(all)

Cite this

Analysis of serum and urinal copper and zinc in chinese northeast population with the prediabetes or diabetes with and without complications. / Xu, Jiancheng; Zhou, Qi; Liu, Gilbert; Tan, Yi; Cai, Lu.

In: Oxidative Medicine and Cellular Longevity, 2013.

Research output: Contribution to journalArticle

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