Analysis of the antifungal activity of ketoconazole, zinc pyrithione, and ciclopirox olamine against Pityrosporum ovale. A diffusion assay for cultures in solid media

Luis Squiquera, Lilian Plotkin, Irina Mathov, Ricardo Galimberti, Juliana Leoni

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background. Recently dandruff has been associated with a local increment in the number of Pityrosporum yeasts. Due to this fact, several anti-dandruff shampoos containing antifungals have been marketed. Objective. We studied the sensitivity of Pityrosporum ovale (PO) to three different groups of antimycotics (ketoconazole, Zn pyrithione, and ciclopirox olamine). Methods/Results. The drugs were tested by an inhibition assay in solid medium. Ketoconazole proved to be the most effective drug in inhibiting PO growth in a dose-dependent fashion. The results of our evaluation revealed that the inhibitory effects of the drugs were ketoconazole > Zn pyrithione > ciclopirox olamine. Conclusion. We postulate that the diffusion assay is a reliable medium for evaluating the effectiveness of antifungals contained in anti-dandruff shampoos.

Original languageEnglish (US)
Pages (from-to)26-29
Number of pages4
JournalJournal of the European Academy of Dermatology and Venereology : JEADV
Volume7
Issue number1
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

ciclopirox
Dandruff
Malassezia
Ketoconazole
Pharmaceutical Preparations
Yeasts
Growth
pyrithione zinc

Keywords

  • Antifungals
  • Ketoconazole
  • Octopirox
  • Pityrosporum ovale
  • Zinc pyrithione

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

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title = "Analysis of the antifungal activity of ketoconazole, zinc pyrithione, and ciclopirox olamine against Pityrosporum ovale. A diffusion assay for cultures in solid media",
abstract = "Background. Recently dandruff has been associated with a local increment in the number of Pityrosporum yeasts. Due to this fact, several anti-dandruff shampoos containing antifungals have been marketed. Objective. We studied the sensitivity of Pityrosporum ovale (PO) to three different groups of antimycotics (ketoconazole, Zn pyrithione, and ciclopirox olamine). Methods/Results. The drugs were tested by an inhibition assay in solid medium. Ketoconazole proved to be the most effective drug in inhibiting PO growth in a dose-dependent fashion. The results of our evaluation revealed that the inhibitory effects of the drugs were ketoconazole > Zn pyrithione > ciclopirox olamine. Conclusion. We postulate that the diffusion assay is a reliable medium for evaluating the effectiveness of antifungals contained in anti-dandruff shampoos.",
keywords = "Antifungals, Ketoconazole, Octopirox, Pityrosporum ovale, Zinc pyrithione",
author = "Luis Squiquera and Lilian Plotkin and Irina Mathov and Ricardo Galimberti and Juliana Leoni",
year = "1996",
doi = "10.1016/0926-9959(96)00013-X",
language = "English (US)",
volume = "7",
pages = "26--29",
journal = "Journal of the European Academy of Dermatology and Venereology",
issn = "0926-9959",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Analysis of the antifungal activity of ketoconazole, zinc pyrithione, and ciclopirox olamine against Pityrosporum ovale. A diffusion assay for cultures in solid media

AU - Squiquera, Luis

AU - Plotkin, Lilian

AU - Mathov, Irina

AU - Galimberti, Ricardo

AU - Leoni, Juliana

PY - 1996

Y1 - 1996

N2 - Background. Recently dandruff has been associated with a local increment in the number of Pityrosporum yeasts. Due to this fact, several anti-dandruff shampoos containing antifungals have been marketed. Objective. We studied the sensitivity of Pityrosporum ovale (PO) to three different groups of antimycotics (ketoconazole, Zn pyrithione, and ciclopirox olamine). Methods/Results. The drugs were tested by an inhibition assay in solid medium. Ketoconazole proved to be the most effective drug in inhibiting PO growth in a dose-dependent fashion. The results of our evaluation revealed that the inhibitory effects of the drugs were ketoconazole > Zn pyrithione > ciclopirox olamine. Conclusion. We postulate that the diffusion assay is a reliable medium for evaluating the effectiveness of antifungals contained in anti-dandruff shampoos.

AB - Background. Recently dandruff has been associated with a local increment in the number of Pityrosporum yeasts. Due to this fact, several anti-dandruff shampoos containing antifungals have been marketed. Objective. We studied the sensitivity of Pityrosporum ovale (PO) to three different groups of antimycotics (ketoconazole, Zn pyrithione, and ciclopirox olamine). Methods/Results. The drugs were tested by an inhibition assay in solid medium. Ketoconazole proved to be the most effective drug in inhibiting PO growth in a dose-dependent fashion. The results of our evaluation revealed that the inhibitory effects of the drugs were ketoconazole > Zn pyrithione > ciclopirox olamine. Conclusion. We postulate that the diffusion assay is a reliable medium for evaluating the effectiveness of antifungals contained in anti-dandruff shampoos.

KW - Antifungals

KW - Ketoconazole

KW - Octopirox

KW - Pityrosporum ovale

KW - Zinc pyrithione

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