Analysis of the associations between lung function and clinical features in preschool children with Cystic Fibrosis

Clement L. Ren, Margaret Rosenfeld, Oscar H. Mayer, Stephanie Davis, Margaret Kloster, Robert G. Castile, Peter W. Hiatt, Meeghan Hart, Robin Johnson, Paul Jones, Lyndia C. Brumback, Gwendolyn S. Kerby

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective To analyze cross-sectional and longitudinal associations between lung function measures and clinical features in a cohort of preschool children with cystic fibrosis (CF). Methods Longitudinal eight-center observational study of children with CF aged 36-60 months at enrollment, who underwent semiannual pulmonary function tests (PFTs) for up to 2 years consisting of spirometry (all 8 sites), forced oscillometry (FO, 5 sites), and measures of thoracoabdominal asynchrony using respiratory inductive plethysmography (IP, 5 sites). Results Ninety-three subjects were enrolled; 181 acceptable spirometry measurements from 71 subjects, 128 FO from 47 subjects, and 142 IP from 50 subjects were available for analysis. Cross sectional analyses did not detect an association between any PFT parameter at enrollment and Pseudomonas aeruginosa (Pa) status, CF gene mutation class, Wisconsin cough score, Shwachman score, environmental tobacco smoke exposure, family history of asthma, or nutritional indices. In longitudinal analyses, Pa infection within 6 months preceding enrollment was associated with a significantly greater rate of decline in z-scores for forced expiratory flow between 25 and 75% of forced vital capacity (FEF 25-75) (-1.3 vs. -0.4 Z scores/year, P=0.024) and greater thoracoabdominal asynchrony measured by IP (mean phase angle difference 4.6°, P=0.004). No other significant longitudinal associations were observed. Conclusions Prior Pa infection is associated with a greater rate of decline in FEF 25-75 z-score and mild thoracoabdominal asynchrony in preschool children with CF. In this multicenter US study, significant associations between other lung function measures and clinical features were not detected.

Original languageEnglish (US)
Pages (from-to)574-581
Number of pages8
JournalPediatric Pulmonology
Volume47
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Preschool Children
Cystic Fibrosis
Pseudomonas aeruginosa
Pseudomonas Infections
Lung
Spirometry
Respiratory Function Tests
Oscillometry
Cross-Sectional Studies
Nutrition Assessment
Plethysmography
Vital Capacity
Cough
Smoke
Multicenter Studies
Tobacco
Observational Studies
Asthma
Mutation
Genes

Keywords

  • oscillometry
  • plethysmography
  • Pseudomonas aeruginosa
  • spirometry

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Analysis of the associations between lung function and clinical features in preschool children with Cystic Fibrosis. / Ren, Clement L.; Rosenfeld, Margaret; Mayer, Oscar H.; Davis, Stephanie; Kloster, Margaret; Castile, Robert G.; Hiatt, Peter W.; Hart, Meeghan; Johnson, Robin; Jones, Paul; Brumback, Lyndia C.; Kerby, Gwendolyn S.

In: Pediatric Pulmonology, Vol. 47, No. 6, 06.2012, p. 574-581.

Research output: Contribution to journalArticle

Ren, CL, Rosenfeld, M, Mayer, OH, Davis, S, Kloster, M, Castile, RG, Hiatt, PW, Hart, M, Johnson, R, Jones, P, Brumback, LC & Kerby, GS 2012, 'Analysis of the associations between lung function and clinical features in preschool children with Cystic Fibrosis', Pediatric Pulmonology, vol. 47, no. 6, pp. 574-581. https://doi.org/10.1002/ppul.21590
Ren, Clement L. ; Rosenfeld, Margaret ; Mayer, Oscar H. ; Davis, Stephanie ; Kloster, Margaret ; Castile, Robert G. ; Hiatt, Peter W. ; Hart, Meeghan ; Johnson, Robin ; Jones, Paul ; Brumback, Lyndia C. ; Kerby, Gwendolyn S. / Analysis of the associations between lung function and clinical features in preschool children with Cystic Fibrosis. In: Pediatric Pulmonology. 2012 ; Vol. 47, No. 6. pp. 574-581.
@article{eb98d9403a744fc4a9790fa74b65b11b,
title = "Analysis of the associations between lung function and clinical features in preschool children with Cystic Fibrosis",
abstract = "Objective To analyze cross-sectional and longitudinal associations between lung function measures and clinical features in a cohort of preschool children with cystic fibrosis (CF). Methods Longitudinal eight-center observational study of children with CF aged 36-60 months at enrollment, who underwent semiannual pulmonary function tests (PFTs) for up to 2 years consisting of spirometry (all 8 sites), forced oscillometry (FO, 5 sites), and measures of thoracoabdominal asynchrony using respiratory inductive plethysmography (IP, 5 sites). Results Ninety-three subjects were enrolled; 181 acceptable spirometry measurements from 71 subjects, 128 FO from 47 subjects, and 142 IP from 50 subjects were available for analysis. Cross sectional analyses did not detect an association between any PFT parameter at enrollment and Pseudomonas aeruginosa (Pa) status, CF gene mutation class, Wisconsin cough score, Shwachman score, environmental tobacco smoke exposure, family history of asthma, or nutritional indices. In longitudinal analyses, Pa infection within 6 months preceding enrollment was associated with a significantly greater rate of decline in z-scores for forced expiratory flow between 25 and 75{\%} of forced vital capacity (FEF 25-75) (-1.3 vs. -0.4 Z scores/year, P=0.024) and greater thoracoabdominal asynchrony measured by IP (mean phase angle difference 4.6°, P=0.004). No other significant longitudinal associations were observed. Conclusions Prior Pa infection is associated with a greater rate of decline in FEF 25-75 z-score and mild thoracoabdominal asynchrony in preschool children with CF. In this multicenter US study, significant associations between other lung function measures and clinical features were not detected.",
keywords = "oscillometry, plethysmography, Pseudomonas aeruginosa, spirometry",
author = "Ren, {Clement L.} and Margaret Rosenfeld and Mayer, {Oscar H.} and Stephanie Davis and Margaret Kloster and Castile, {Robert G.} and Hiatt, {Peter W.} and Meeghan Hart and Robin Johnson and Paul Jones and Brumback, {Lyndia C.} and Kerby, {Gwendolyn S.}",
year = "2012",
month = "6",
doi = "10.1002/ppul.21590",
language = "English (US)",
volume = "47",
pages = "574--581",
journal = "Pediatric Pulmonology",
issn = "8755-6863",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - Analysis of the associations between lung function and clinical features in preschool children with Cystic Fibrosis

AU - Ren, Clement L.

AU - Rosenfeld, Margaret

AU - Mayer, Oscar H.

AU - Davis, Stephanie

AU - Kloster, Margaret

AU - Castile, Robert G.

AU - Hiatt, Peter W.

AU - Hart, Meeghan

AU - Johnson, Robin

AU - Jones, Paul

AU - Brumback, Lyndia C.

AU - Kerby, Gwendolyn S.

PY - 2012/6

Y1 - 2012/6

N2 - Objective To analyze cross-sectional and longitudinal associations between lung function measures and clinical features in a cohort of preschool children with cystic fibrosis (CF). Methods Longitudinal eight-center observational study of children with CF aged 36-60 months at enrollment, who underwent semiannual pulmonary function tests (PFTs) for up to 2 years consisting of spirometry (all 8 sites), forced oscillometry (FO, 5 sites), and measures of thoracoabdominal asynchrony using respiratory inductive plethysmography (IP, 5 sites). Results Ninety-three subjects were enrolled; 181 acceptable spirometry measurements from 71 subjects, 128 FO from 47 subjects, and 142 IP from 50 subjects were available for analysis. Cross sectional analyses did not detect an association between any PFT parameter at enrollment and Pseudomonas aeruginosa (Pa) status, CF gene mutation class, Wisconsin cough score, Shwachman score, environmental tobacco smoke exposure, family history of asthma, or nutritional indices. In longitudinal analyses, Pa infection within 6 months preceding enrollment was associated with a significantly greater rate of decline in z-scores for forced expiratory flow between 25 and 75% of forced vital capacity (FEF 25-75) (-1.3 vs. -0.4 Z scores/year, P=0.024) and greater thoracoabdominal asynchrony measured by IP (mean phase angle difference 4.6°, P=0.004). No other significant longitudinal associations were observed. Conclusions Prior Pa infection is associated with a greater rate of decline in FEF 25-75 z-score and mild thoracoabdominal asynchrony in preschool children with CF. In this multicenter US study, significant associations between other lung function measures and clinical features were not detected.

AB - Objective To analyze cross-sectional and longitudinal associations between lung function measures and clinical features in a cohort of preschool children with cystic fibrosis (CF). Methods Longitudinal eight-center observational study of children with CF aged 36-60 months at enrollment, who underwent semiannual pulmonary function tests (PFTs) for up to 2 years consisting of spirometry (all 8 sites), forced oscillometry (FO, 5 sites), and measures of thoracoabdominal asynchrony using respiratory inductive plethysmography (IP, 5 sites). Results Ninety-three subjects were enrolled; 181 acceptable spirometry measurements from 71 subjects, 128 FO from 47 subjects, and 142 IP from 50 subjects were available for analysis. Cross sectional analyses did not detect an association between any PFT parameter at enrollment and Pseudomonas aeruginosa (Pa) status, CF gene mutation class, Wisconsin cough score, Shwachman score, environmental tobacco smoke exposure, family history of asthma, or nutritional indices. In longitudinal analyses, Pa infection within 6 months preceding enrollment was associated with a significantly greater rate of decline in z-scores for forced expiratory flow between 25 and 75% of forced vital capacity (FEF 25-75) (-1.3 vs. -0.4 Z scores/year, P=0.024) and greater thoracoabdominal asynchrony measured by IP (mean phase angle difference 4.6°, P=0.004). No other significant longitudinal associations were observed. Conclusions Prior Pa infection is associated with a greater rate of decline in FEF 25-75 z-score and mild thoracoabdominal asynchrony in preschool children with CF. In this multicenter US study, significant associations between other lung function measures and clinical features were not detected.

KW - oscillometry

KW - plethysmography

KW - Pseudomonas aeruginosa

KW - spirometry

UR - http://www.scopus.com/inward/record.url?scp=84861228035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861228035&partnerID=8YFLogxK

U2 - 10.1002/ppul.21590

DO - 10.1002/ppul.21590

M3 - Article

C2 - 22081584

AN - SCOPUS:84861228035

VL - 47

SP - 574

EP - 581

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

SN - 8755-6863

IS - 6

ER -