Analysis of the origins and early fates of neural crest cells in caudal regions of avian embryos

Gary C. Schoenwolf, Nancy B. Chandler, Jodi Smith

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Holmdahl divided vertebrate embryogenesis into two phases called primary and secondary body development. Three primary germ layers are delineated during primary body development and undergo morphogenesis to form primary organ rudiments. In contrast, during secondary body development, the tail bud (a mesenchymal mass of cells located at the caudal end of the embryo and derived principally from Hensen's node) directly forms secondary organ rudiments. We have been testing Holmdahl's concept of primary and secondary body development by mapping the embryonic structures that originate from the tail bud. In the present study, we examined the origins of neural crest cells in caudal regions of avian embryos and observed two populations: primary neural crest cells derived from ectoderm and secondary neural crest cells derived from tail bud. Both types of neural crest cells originate locally, and little or no displacement of these cells occurs along the longitudinal axis. Some secondary neural crest cells seem to colonize the surface epithelium, forming a mosaic derived from both ectoderm and tail bud. Other secondary neural crest cells form spinal ganglia, differentiating as sensory neurons, satellite cells, and Schwann cells. Despite their strikingly different origins and locations, primary and secondary neural crest cells give rise to similar structures.

Original languageEnglish (US)
Pages (from-to)467-479
Number of pages13
JournalDevelopmental Biology
Volume110
Issue number2
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Neural Crest
Embryonic Structures
Tail
Ectoderm
Embryonic Organizers
Germ Layers
Schwann Cells
Spinal Ganglia
Sensory Receptor Cells
Morphogenesis
Embryonic Development
Vertebrates
Epithelium
Population

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Analysis of the origins and early fates of neural crest cells in caudal regions of avian embryos. / Schoenwolf, Gary C.; Chandler, Nancy B.; Smith, Jodi.

In: Developmental Biology, Vol. 110, No. 2, 1985, p. 467-479.

Research output: Contribution to journalArticle

Schoenwolf, Gary C. ; Chandler, Nancy B. ; Smith, Jodi. / Analysis of the origins and early fates of neural crest cells in caudal regions of avian embryos. In: Developmental Biology. 1985 ; Vol. 110, No. 2. pp. 467-479.
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